Neurologist and Alzheimer disease scientist at Brigham and Women’s Hospital. My lab studies beta-amyloid aggregates as they occur in human brain. Also TDP-43 biomarkers. Associate PD for research at MGB neurology residency program. sternlab.bwh.harvard.edu
Andrew Stern
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Do we grow wiser as we age?
I spent 15+ years chasing glam journals, wasting time and energy (and frustrating my team and co-authors).
I don’t want to wake up at 70 and realize my life went into convincing a few editors my work was trendy enough.
Enough. I’ll try to be smarter.
Encouraged to see that the FY27 LHHS appropriations bill emerged from House subcommittee with a ~3% increase in NIH funding compared to FY26. But this needs to be more like 20% to make up for a decade of stagnation.
Updating this graph for the holidays 🎁
(datapoints are a selection of journals publishing in neuroscience)
My favorite NIH entity is the Council of Councils, which sounds like it might launch a war to defend Naboo.
Introducing Nature Baubles, the latest addition to Nature Portfolio. open.substack.com/pub/andrewms...
Some progress toward a sensitive test for TDP-43 diseases. www.massgeneralbrigham.org/en/about/new...
We were unable to find support for the claim that lecanemab binds a different, more soluble, human target than aducanumab and donanemab. Antibody preference for plaques vs CAA is unlikely to explain differences in ARIA-E rates. alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
We found that Aβ fibrils at plaque edges form a complex with the U1 snRNP. U1-70k is the most-correlated insoluble protein with Aβ in AD. Previously thought to be intracellular in tangles, but we find it’s directly bound to Aβ. With @raflynn5.bsky.social. www.biorxiv.org/content/10.6...
Updates to the submission process for LOIs and grants requesting more than $500K in any budget periods. grants.nih.gov/grants/guide...
