Bacteria vs phage: new layers in NAD+ centric arms race
aRES is bacterial protein that blocks phage infection by cleaving NAD+ into ADPR-1P & nicotinamide. Phages counter using NAD+ reconstitution pathway w/ADPR-1P & nicotinamide as substrates
www.cell.com/cell-host-mi...
Osterman et al. describe a bacterial defense protein that, once triggered by the phage
DNA polymerase, blocks infection by cleaving NAD+ into ADPR-1P and nicotinamide. They
show how phages counter thi...
