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Did you read our paper applying SUM-seq in macrophages, T-cells and iPSCs (www.nature.com/articles/s41...) and think: I want to try this cost-effective single cell RNA & ATAC-seq method myself? 🧬 Find the complete protocol including tips, troubleshooting and timing now in Nature Protocols
3mo
www.nature.com
This work presents SUM-seq, an ultra-high-throughput method for co-profiling chromatin accessibility and gene expression in single nuclei across multiplexed samples, advancing the study of gene regula...
Single-cell ultra-high-throughput multiplexed chromatin and RNA profiling reveals gene regulatory dynamics - Nature Methods
Annique Claringbould
New Article! Single-cell ultra-high-throughput multiplexed chromatin accessibility and gene expression sequencing (SUM-seq)
3mo
dlvr.it
Nature Protocols, Published online: 26 February 2026; doi:10.1038/s41596-025-01310-0A protocol for simultaneous profiling of chromatin accessibility and gene expression in single nuclei that permits sample multiplexing via sample-specific in situ barcoding and high-throughput droplet overloading.
Single-cell ultra-high-throughput multiplexed chromatin accessibility and gene expression sequencing (SUM-seq)
Nature Protocols