Using a stochastic dynamical model, Grodem et al show that, before age 60, inter-individual differences in neuroanatomical volumes almost exclusively reflect stable differences between individuals, rather than systematic differences in rate-of-change:
doi.org/10.1162/IMAG.a.1242
MRC Cognition and Brain Sciences Unit, University of Cambridge
New paper in Imaging Neuroscience by Edvard O.S. Grødem, Anders M. Fjell, et al:
Stable individual differences dominate adult brain volume variation until later life
doi.org/10.1162/IMAG...
Paper out now involving LIP colleagues @brandmaier.bsky.social and Ulman Lindenberger!
Imaging Neuroscience
Center for Lifespan Psychology, MPI for Human Development
Cognitive function at age 13 predicts dementia 60 years later, even controlling for cardiovascular and cardiometabolic risk. @KWalhovd www.medrxiv.org/content/10.6...
Interested in neuroimaging and cognition in aging and want to work with us? We have an open position @KWalhovd @LCBC_UiO 2411.webcruiter.no/Main2/Recrui...
Anders M Fjell
Anders M Fjell
Another implication: BrainAge models usually do not reflect aging differences -> it is critical to distinguish stable early-adulthood levels from systematic differences in change when studying adult brain aging
Use of brain age models frequently lead to wrong conclusions - unfortunately it is not easy to fix. Fortunately, there are better alternatives. @edvardg.bsky.social @fmrib-steve.bsky.social @didacvp.bsky.social @maxwellelliott.bsky.social @k.b.walhovd www.medrxiv.org/content/10.6...
How long can humans live? "If anti-ageing research worked, even a little, it would be obvious. An eight-year reduction in biological age would halve the risk of death. It would not need marketing." www.nature.com/articles/d41...
Anders M Fjell
Up to age 60, adult brain volume completely dominated by stable individual diffs. At 80 yrs, up to 50% reflects differences in change. Interpretation: 1) We change similarly up to 60. 2) Group comparisons often not reflecting changes.
@Edvardosg @LCBC_UiO direct.mit.edu/imag/article...
Anders M Fjell
Anders M Fjell
Abstract. Individual differences in the volumes of brain structures are often linked to various conditions, including Alzheimer’s disease, schizophrenia, and overall brain health. However, it remains ...
Up to age 60, adult brain volume completely dominated by stable individual diffs. At 80 yrs, up to 50% reflects differences in change. Interpretation: 1) We change similarly up to 60. 2) Group comparisons often not reflecting changes.
@Edvardosg @LCBC_UiO direct.mit.edu/imag/article...
Abstract. Individual differences in the volumes of brain structures are often linked to various conditions, including Alzheimer’s disease, schizophrenia, and overall brain health. However, it remains ...
