Professor of psychology. Center for Lifespan Changes in Brain and Cognition. University of Oslo. Interested in the brain from the start to the end. www.lcbc.uio.no
Anders M Fjell
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Use of brain age models frequently lead to wrong conclusions - unfortunately it is not easy to fix. Fortunately, there are better alternatives. @edvardg.bsky.social @fmrib-steve.bsky.social @didacvp.bsky.social @maxwellelliott.bsky.social @k.b.walhovd www.medrxiv.org/content/10.6...
Paper out now involving LIP colleagues @brandmaier.bsky.social and Ulman Lindenberger!
How long can humans live? "If anti-ageing research worked, even a little, it would be obvious. An eight-year reduction in biological age would halve the risk of death. It would not need marketing." www.nature.com/articles/d41...
Using a stochastic dynamical model, Grodem et al show that, before age 60, inter-individual differences in neuroanatomical volumes almost exclusively reflect stable differences between individuals, rather than systematic differences in rate-of-change:
doi.org/10.1162/IMAG.a.1242
New paper in Imaging Neuroscience by Edvard O.S. Grødem, Anders M. Fjell, et al:
Stable individual differences dominate adult brain volume variation until later life
doi.org/10.1162/IMAG...
Another implication: BrainAge models usually do not reflect aging differences -> it is critical to distinguish stable early-adulthood levels from systematic differences in change when studying adult brain aging
Cognitive function at age 13 predicts dementia 60 years later, even controlling for cardiovascular and cardiometabolic risk. @KWalhovd www.medrxiv.org/content/10.6...
