| CRISPR, Plasmid Biology, Bacterial EcoEvo & AMR | Sci-Illustrator |
Postdoc at the Evolutionary Biology lab (Gordo lab), Gulbenkian Institute for Molecular Medicine @gimminstitute.bsky.social
| She/Her | From 🇪🇸&🇵🇹 | 💜
Alicia Calvo-Villamañán
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Shoutout to this amazing piece of work! Do you want to know how chronic gut inflammation affects bacterial and MGEs evolution? Give this thread a read, it is fire 🔥! (ba-dum-tss)
What if multireplicon plasmids are not an oddity, but an evolutionary strategy?
We found that they are common, more mobile, broader-host-range, and enriched in AMR.
Even more interesting: their assembly doesn’t look random. 👀
Paper preprint: www.biorxiv.org/content/10.6...
Thread below!🧵👇
This year's GIMM fest is all about microbial evo-evo and health&disease 🧫
Two days speaking about microbes by the lovely Lisbon coast, need I say more?
I am excited to share our latest paper, Uniform bacterial genetic diversity along the gut, now out in Nature Communications! www.nature.com/articles/s41.... (1/n)
Phages invented sgRNAs before humans!! 🧬
Obviously, for mischief… 😈
Loved seeing this story unfold!
New paper out! 🔈
Genomic Characterization of the RyC collection: 50 Multidrug Resistant Clinical Isolates of Escherichia coli and Klebsiella spp.
50 MDR gut isolates, 2 sequencing platforms, 4 “omes,” and 1 mission: provide a resource to decode AMR and MGE dynamics
www.biorxiv.org/content/10.6...
So happy to see this finally published in @plosbiology.org!
This is the first chapter of @julielebris.bsky.social PhD thesis demonstrating how capsules are exchanged by plug-and-play dynamics
w/ @epcrocha.bsky.social
#microsky @klebclub.bsky.social
Link below-
Check out her 🧵 for more details!
Horizontal gene transfer is often depicted as a process distributing pre-existing functions to novel genetic backgrounds. Yet HGT can also increase the rate of functional innovation after transfer. Here's a brief review on the topic: ecoevorxiv.org/repository/v... #evosky #microsky
www.biorxiv.org
Excited to share our new paper out today in @science.org 🎉
We show that HGT via natural competence drives diversification of chromosomal integrons in V. cholerae 🤩
Below a 🧵 on key findings incl. background on natural competence in V. cholerae 1/
#microsky #phagesky
www.science.org/doi/10.1126/...
Alicia Calvo-Villamañán
Ignacio (Nacho) de Quinto
www.biorxiv.org
Alicia Calvo-Villamañán
Nandita Garud
New preprint alert!!! 🚀🤓 We are very happy to finally share this with the world — the result of seven years of work and a new tool to study integrons and discover new functions encoded in these bacterial platforms.
If you want to know more, here is a thread 🧵
www.biorxiv.org/content/10.6...
🧵 New preprint out! We asked: what happens to gut bacteria when the intestine is under chronic inflammation (IBD)? Turns out, the host's inflammatory state reshapes how they evolve, and the results are pretty striking. A thread 👇
How complex multi-gene systems evolve across genetic backgrounds without disruptive epistasis remains unclear, particularly in highly exchangeable loci such as the capsule of Klebsiella pneumoniae. Th...
