Curious how immune systems differentiate partner from pathogen:
bacteria-phage | macrophage-cancer | orchid-fungi
Genetics PhD candidate @stanford
Formerly orchid ecologist @smithsonian
Simone Alma Evans
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Protein-templated DRT3 expands the textbook definition of reverse transcriptases further! Beautiful paper led by Pujuan Deng, Hyunbin Lee, and Carlo Armijo!
This work was a collaboration with Collin Chiu, @maxewilkinson.bsky.social, and a great team!
Excited to share our preprint on terminase sensing by Avs2 and Upx! We solved a cryo-EM structure of Avs2 with terminase and found an unexpected "bridging" ATP at their interface. In contrast, Upx is predicted to bind an unfolded ATPase domain via β-augmentation.
www.biorxiv.org/content/10.6...
Simone Alma Evans
Simone Alma Evans
Vaults. They are cell biology's greatest puzzle! This preprint from Martin Beck's lab shows them docked on ER membranes with a ribosome inside. What on earth is going on there??
#CellBiology #WTFology
www.biorxiv.org/content/10.6...
Simone Alma Evans
Amazing findings in geometry-based immune activation! Two bacterial defence systems detect phage-encoded ring oligomers, assemble high-order molecular complexes, and trigger abortive infection.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
With Eugene Koonin, we wrote a rather comprehensive review on the origin, evolution and organization of the #virosphere. We describe all 10 viral realms and the logic behind them, and so much more. Check it out! comptes-rendus.academie-sciences.fr/biologies/ar...
Bacterial genomes encode a rich repertoire of antiphage systems, but we still know surprisingly little about when these systems are actually expressed.
In this preprint, Lucas Paoli et al, ask what shapes antiphage systems expression in native contexts.
www.biorxiv.org/content/10.6...
I’m thrilled to share our work on phage triggers of the bacterial immune system in its final form @natmicrobiol.nature.com www.nature.com/articles/s41...
