What determines cell-cycle-dependent loading of human CENP-A?
Bypassing the MIS18α/β scaffold via artificial M18BP1 dimerization allows @andrea-musacchio.bsky.social and coworkers to identify determinants, including structure of the M18BP1 SANTA domain
link.springer.com/article/10.1...
It’s out! 🥳 Excited to share our new paper (with Kai Walstein, @andrea-musacchio.bsky.social and all others) on the role of M18BP1 in CENP-A loading!
“M18BP1 valency and a distributed interaction footprint determine epigenetic centromere specification in humans”
link.springer.com/article/10.1...
The histone H3 variant CENP-A is considered an epigenetic landmark of centromeres. Its deposition reflects cell-cycle-regulated assembly of M18BP1, HJURP, and PLK1 on a divalent MIS18α/β scaffold. The...
The histone H3 variant CENP-A is considered an epigenetic landmark of centromeres. Its deposition reflects cell-cycle-regulated assembly of M18BP1, HJURP, and PLK1 on a divalent MIS18α/β scaffold. The...
link.springer.com
Arianna Esposito Verza, @andrea-musacchio.bsky.social et al describe the long-sought-after mechanism of Bora dependency of PLK1 activation by Aurora A kinase during mitotic entry
Another #RefereedPreprint ℅ @reviewcommons.org
link.springer.com/article/10.1...
Our manuscript "In vivo CRISPR/Cas9 screens identify new regulators of B cell activation and plasma cell differentiation" was just published in the @jem.org, @rupress.org!!!
Plasma cells are the immune system’s antibody factories, and they originate from B-cells.
Researchers from our Busslinger lab developed a new CRISPR screening method to find the genes that control this transition inside living mice:
Louisa Hill
The EMBO Journal
🌍Open call: Junior Group Leader positions!
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Two new papers from the lab published in The EMBO Journal!
link.springer.com/article/10.1...
By Kai Walstein, @louisa-hill.bsky.social and others – On role of M18BP1 in CENP-A loading
link.springer.com/article/10.1...
By Arianna Esposito Verza and others – On mechanism of activation of PLK1
