New in @quantamagazine.bsky.social: the science of cytoplasmic crowding. From Liam Holt & Simone Reber's work to our discovery that in vivo cytoplasm is 50x more crowded than cultured cells. Thanks @danstarrucdavis.bsky.social & @gabepopkin.bsky.social! www.quantamagazine.org/the-biophysi...
Dear friends at ASCB, I’ll be giving a talk tomorrow at the minisymposium of Structure, Function and Mechanics of Nuclear Envelope, at 11:00 am in Room 118.
Come talk with me and all other Starr-Luxton Lab folks here at ASCB Matt, Dan and Gant and let’s get connected! #ASCB #CellBio2025
Immune tissue behaves as shapeshifting active living matter as it fights intruders. Using liquid-like multicellular B cell droplets, we show that cytokines control the physical state of immune tissue.
www.biorxiv.org/content/10.1...
youtu.be/QAk2ayoVF0M
#biophysics #immunology #activematter
🎉Check out our new preprint!! 🧬We found that lamin mutations in muscular dystrophy don’t just affect the nucleus — they disrupt a nucleolar–ribosomal axis that reorganizes the entire cytoplasm.
Very grateful to @danstarrucdavis.bsky.social, @gwgl.bsky.social and our lab for collaboration & support!
🧬BREAKING!🪱Plot twist: Cells aren't meditation pools, they're overcrowded concerts with VIP ropes everywhere! Our
study reveals worm cells are insanely crowded AND compartmentalized. Ribosomes = packing peanuts, ANC-1 = the bouncer!
www.science.org/doi/10.1126/...
Grateful to my mentors @danstarrucdavis.bsky.social and @gwgl.bsky.social. Huge thanks to @HongyanHao and @DanielElnatan for their key contributions, and to our collaborator @liamholt.bsky.social. Thanks to @alleninstitute.org and NIGMS for the funding and support to our research.
Thrilled to share that a big piece of my thesis here in the Starr–Luxton is now out in Science Advances! We discovered that the cytoplasm of living animal tissues is extremely crowded and constrained, maintained by ribosomes and the giant KASH protein ANC-1.
www.science.org/doi/10.1126/...
🚨Our fabulous graduate student Selin's paper on how the KASH protein UNC-83 regulates the activity of kinesin-1 to control developmental stage-specific nuclear migration is out! Another great collaboration between the Starr-Luxton and MOM labs.
www.sciencedirect.com/science/arti...
Ellen Gregory, @gwgl.bsky.social‬, & @danstarrucdavis.bsky.social‬ show how heterochromatin helps cell nuclei migrate through tight spaces in #Celegans! Learn more in #GENETICS about the process of heterochromatin anchoring to the nuclear periphery that supports nuclei squeezing: buff.ly/kZttVdX