Author Correction: [2+2] Photocycloaddition reactions of sulfinylamines with alkenes to access β-sultam derivatives #chemsky
Designed for forever #chemsky
Aromatic ring flips reveal reshaping of protein dynamics in crystals and complexes #chemsky
Copper-catalysed site-selective arylation of pyrazoles #chemsky
Divergent and precise alkaloid remodelling with a small suite of reactions #chemsky
Ligand-modulated metal–radical polarity match enables general 1,2-dicarbofunctionalization of ethylene #chemsky
Charge transport through linear carbon atomic chains #chemsky
Catalytic endo-stereoselective [2+2] cycloaddition of norbornadienes with internal alkynes #chemsky
Distinct energetic blueprints diversify function of conserved protein folds #chemsky
Cyclophane-based shielding strategy for singly dispersed graphene nanoribbons #chemsky
Nature Chemistry, Published online: 10 June 2026; doi:10.1038/s41557-026-02198-3Author Correction: [2+2] Photocycloaddition reactions of sulfinylamines with alkenes to access β-sultam derivatives
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Nature Chemistry, Published online: 05 June 2026; doi:10.1038/s41557-026-02162-1Yuanqiang Sun, Daniel Reddy, and Lishen Zhang explore the central paradox of PTFE: the very molecular design that enabled this industrial marvel has also established the material and its chemical relatives as an enduring environmental crisis.
Nature Chemistry, Published online: 10 June 2026; doi:10.1038/s41557-026-02155-0The extent to which crystal packing constrains protein dynamics is hard to decipher. Now a combination of NMR, crystallography and molecular dynamics simulations show that intermolecular contacts can slow ring flips down in crystals or accelerated them in complexes. A thermodynamic and structural analysis provides insights into the origins of the elevated free-energy barrier in crystals.
Nature Chemistry, Published online: 05 June 2026; doi:10.1038/s41557-026-02164-zA deconstructive alkaloid remodelling strategy comprising a concise set of robust transformations is introduced. Twenty-six altered frameworks are synthesized, requiring an average of ~1.8 steps per analogue. In cellulo evaluation across ten cancer cell lines indicates that an expanded amine bridge and a deconstructed tricyclic analogue exhibit micromolar and nanomolar level activities, respectively.
Nature Chemistry, Published online: 10 June 2026; doi:10.1038/s41557-026-02177-8Selective radical capture remains a central challenge in transition metal-catalysed transformations involving multiple radical intermediates. Now a ligand-modulated metal–radical polarity-match mechanism exploiting electronic bias for selective radical capture has been identified. This principle enables general photoredox/copper-catalysed 1,2-dicarbofunctionalization of ethylene, providing modular access to structurally diverse 1,2-dicarbofunctionalized ethanes.
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Nature Chemistry, Published online: 05 June 2026; doi:10.1038/s41557-026-02167-wThe endo-facial stereoselective transformation of norbornadiene (NBD) remains underdeveloped. Now a nickel(0)-catalysed endo-selective [2+2] cycloaddition of NBDs with unactivated internal alkynes is reported, enabled by ligand-mediated facial differentiation of NBDs and nickel-controlled configuration of a key intermediate. This scalable method provides an expedient route to synthetically useful endo-tricyclononadienes and substituted homocubanes.
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Nature Chemistry, Published online: 05 June 2026; doi:10.1038/s41557-026-02163-0Proteins sharing a common fold can evolve strikingly different functions, but the underlying energetic logic is often hidden. Now, hydrogen exchange–mass spectrometry reveals conserved energetic ‘blueprints’ that distinguish Venus flytrap transcription factors from transport proteins, uncovering molecular switches for allostery and enabling rational tuning of ligand sensitivity.
Nature Chemistry, Published online: 05 June 2026; doi:10.1038/s41557-026-02172-zThe integration of graphene nanoribbons into single-ribbon devices is impeded by strong inter-ribbon aggregation. Now a cyclophane-based shielding approach has been developed to sterically protect the graphene nanoribbon backbone while imparting internal strain, enabling singly dispersed graphene nanoribbons and modulation of their optoelectronic properties.
Nature Chemistry, Published online: 12 June 2026; doi:10.1038/s41557-026-02148-zN-aryl pyrazole is a prevalent motif among pharmaceuticals across various therapeutic areas but can be challenging to synthesize due to the high similarity of the two nitrogen atoms. Now it has been shown that the use of copper catalysis and arynes provides a switchable protocol to access both regioisomers.
Nature Chemistry, Published online: 12 June 2026; doi:10.1038/s41557-026-02175-wExtreme reactivity has long hindered the study of linear atomic carbon chains (carbyne). Now it has been shown that transmetallation of suitable precursors overcomes stability issues, delivering 1D Au|Cn|Au junctions that sustain high currents through a cumulene ⋯C=C=C=C⋯ valence structure with 12 or more carbon atoms and enabling their potential for 1D electronics.
