An #estimand is effectively a more precise specification of the research question(s) and how the treatment effect is to be estimated (hence estimand). It also precisely describes how so called “intercurrent events” will be handled in the analysis. 2/8
Hebrides 🤩
The cluster trials (cRCT) estimand framework extension outlines what exactly needs to be made explicit in a cluster trial estimand - there are five key things be considered 5/8
“Intercurrent events” are post-randomisation events (eg discontinuation/switching of treatment etc) and the estimand describes how these events will be handled in the analysis. In cluster trials these can happen at both the cluster and the individual level 3/8