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@romihadary.bsky.social and @soreklab.bsky.social 's discovery that sponge proteins constitute enormous families of viral immune evasion factors is now out in @natmicrobiol.nature.com @reneechang.bsky.social and our lab were happy to help with this story! www.nature.com/articles/s41...
Excited to see our work out in @natmicrobiol.nature.com! We uncovered broad functional diversity within phage sponge families🧽. Huge thanks to all coauthors and brilliant collaborators @kranzuschlab.bsky.social @reneechang.bsky.social ! www.nature.com/articles/s41...
Folddisco is now published @natbiotech.nature.com. It’s a fast motif search for similar 3D DISCOntinuous residues like catalytic sites or zinc fingers across the entire protein universe. 📄 www.nature.com/articles/s41... 💾 folddisco.foldseek.com​​​​​​​​​​​​​​​​ 🌐 https://search.foldseek.com/folddisco
Cheap and easy method for nanopore sequencing phage DNA directly from plaques. Proud of lab members Brenna and Patrick for doing this work *with absolutely no help from me* !! www.nature.com/articles/s41...
A new function for RyR domains in nucleotide signaling! Excited to share @riveralopz.bsky.social's story at SISB2026 and the pre-print now. Thanks to @reneechang.bsky.social collaborators in Graham Hatfull's and @soreklab.bsky.social groups @kfreeman.bsky.social @romihadary.bsky.social and Jim Sun
Our paper "Gene ancestries reveal diverse microbial associations during eukaryogenesis.” is finally out in Nature. Eukaryogenesis was likely a gradual process shaped by multiple microbial partners and virus-mediated gene transfer, rather than a single binary symbiosis. doi.org/10.1038/s415...
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www.nature.com
Scientific Reports - Same-day tagmentation PCR-based whole genome sequencing of bacteriophage genomes from a single plaque without DNA extraction
Same-day tagmentation PCR-based whole genome sequencing of bacteriophage genomes from a single plaque without DNA extraction - Scientific Reports
A functional screen reveals phage sponge proteins that bind Pycsar, Thoeris and CBASS signalling molecules to inhibit bacterial immunity.
www.nature.com
Functional diversity of phage sponge proteins that sequester host immune signals - Nature Microbiology
Folddisco enables protein structural motif search in million scale databases.
www.nature.com
A functional screen reveals phage sponge proteins that bind Pycsar, Thoeris and CBASS signalling molecules to inhibit bacterial immunity.
www.nature.com
Structural motif search across the protein universe with Folddisco - Nature Biotechnology
Functional diversity of phage sponge proteins that sequester host immune signals - Nature Microbiology
Romi, thank you so much for all your help with this project—it was great to finally meet you in person at SISB! 😊
Esta nos la sabemos solo los sabineros de verdad! Jajaja
Romi Hadary
Martin Steinegger 🇺🇦
Kranzusch Lab
Kranzusch Lab
Jesse Shapiro
Thank you, Ilya! The NARP1 discovery is one of the coolest phage anti-defense stories out there, so it was exciting to see RyDEP synergize with it. Looking forward to seeing all the metabolism-related immune stories your new lab will put forward!
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Toni Gabaldón
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