Excited to see this out in PNAS. A fabulous project by Adam Pines and the Williams lab: across psychedelics (LSD, Psilo, MDMA), species, and datasets, a very consistent story—reduced propagation of activity into the default mode network (DMN). Congrats Adam! 🧠🍄
www.pnas.org/doi/10.1073/...
Psychedelics may weaken the normal flow of information into higher-order systems that support abstract self-referential processing, allowing perception and cognition to become less constrained. An interesting systems neuroscience account of psychedelic action.