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Congratulations to the Walczak lab for this amazing piece of work just pulisbed on @natcellbio.nature.com A must read!!! This work adds a new letter of the ubiquitin code to immune signaling regulations! www.nature.com/articles/s41...
3mo
www.nature.com
Betrancourt, Cinko et al. identify ANKIB1-mediated K11 ubiquitination and OPTN recruitment as a shared mechanism for driving immune signalling by cGAS, TLR3 and TLR4, with functional relevance in inte...
Lysine-11 ubiquitination drives type-I/III interferon induction by cGAS–STING and Toll-like receptors 3 and 4 - Nature Cell Biology
Gianmaria Liccardi