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Group leader, Liccardi lab, Institute of biochemistry, University of Cologne. We are interested in cell death inflammation and immunity.

Gianmaria Liccardi

Fantastic work in collaboration with @vonkarstedtlab.bsky.social available on Cell Death & Discovery. Ibrutinib sensitises to ferroptosis induction to kill DLBCL. #cancer #lymphoma #dlbcl doi.org/10.1038/s414...

7mo

Our work shows that STING triggers ZBP1-mediated necroptosis independently of TNFR1 and FADD. Inhibiting necroptosis prevents STING-associated vasculopathy with onset in infancy (SAVI), paving the way for cell death inhibition as a therapeutic strategy for STING-driven inflammatory diseases

This work was funded by BCCologne, SFB1530, SFB1399 and the CANTAR network and supported by the SFB_1403

Just found this post from Nature on the AAP of our paper. Soon the official print version…

A special thanks to Henning Walczak for all his support. Thanks also to all other collaborators: Trifunovic lab, Federica Locci, Martin Peifer , Fabrizio De Bendetti, Giusi Prencipe and Antonella Insalaco.

9mo

The STING of death continues! Thanks to @natrevrheum.nature.com (doi.org/10.1038/s415... & rdcu.be/eJjhl ) for highlighting our recent @nature.com paper (doi.org/10.1038/s415...) cell death inhibition as a therapy for autoinflammatory diseases (SAVI) #immunity #celldeath #rheumatology #vasculitis

Congratulations to the Walczak lab for this amazing piece of work just pulisbed on @natcellbio.nature.com A must read!!! This work adds a new letter of the ubiquitin code to immune signaling regulations! www.nature.com/articles/s41...

Gianmaria Liccardi

Thank you @fattoquotidiano.bsky.social for covering our @nature.com article. www.ilfattoquotidiano.it/2025/08/21/m... Reserach article: doi.org/10.1038/s415...

In my lab we are interested in understanding how aberrant activation of cell death & inflammation drive loss of tissue homeostasis and how genetic instability contributes to the loss of this balance. If you are interested in discussing this topic, joining our lab or collaborate please let me know.

I am beyond excited and incredibly proud to share that our work is now out in @nature.com This discovery was made possible thanks to the first author Kostas kelepouras, my fantastic lab , and the unique research environment here in Cologne in collaboration with the Hospital bambino Gesu in Rome.

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Nov 23, 2024

9mo

Cell Death Discovery - Redox destabilization by ibrutinib promotes ferroptosis in diffuse large B-cell lymphoma (DLBCL)

doi.org

Redox destabilization by ibrutinib promotes ferroptosis in diffuse large B-cell lymphoma (DLBCL) - Cell Death Discovery

Gianmaria Liccardi

STING induces ZBP1-mediated necroptosis independently of TNFR1 and FADD - Nature

Nature - STING induces ZBP1-mediated necroptosis independently of TNFR1 and FADD

www.nature.com

Gianmaria Liccardi

Happy to share an incredibly efficient collaboration with @gianmaria-liccardi.bsky.social : Ibrutinib cooperates with #ferroptosis induction to kill #dlbcl www.nature.com/articles/s41...

7mo