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Very excited about our recent preprint- @lindashuyingxu.bsky.social and collabs discover that neutrophils repurpose their nucleolus for storage of pre-made IFN-I to be rapidly released via a nucleolar stress response that results in nucleolar extrusion and secretion. www.biorxiv.org/content/10.6...
#DBfeature VEGF signalling promotes blastema growth and proliferation of both vascular and non-vascular cells during axolotl limb regeneration By Aaron Savage et al. tinyurl.com/3xs4nffs
Absolutely beautiful paper by a core team at the RIKEN in which the telomerase RNA component has (finally) been identified, in the nematode *C. elegans*. Surprisingly, it does not have its own promoter, but is located inside the intron of a germline-expressed gene (nmy-2)! 🤩 doi.org/10.1126/scie...
Really cool paper from Marie-Anne Felix's lab. Genetic variation in set-24 controls the duration of epigenetic inheritance. www.cell.com/current-biol...
16d
3mo
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www.biorxiv.org
Frejacques, Saglio, et al. demonstrate variation among C. elegans wild isolates in the multigenerational memory of an initial RNA interference trigger. Genetic polymorphisms and environmental variable...
www.cell.com
Intraspecific variation in the duration of epigenetic inheritance in wild isolates of C. elegans
Brice Letcher
Developmental Biology
The Allard lab
Christina Stallings
Telomerase is a ribonucleoprotein complex that elongates telomeric DNA, ensuring germline immortality. In this study, we identified the Caenorhabditis elegans telomerase RNA component 1 (terc-1), as t...
Nematode telomerase RNA hitchhikes on introns of germline–up-regulated genes
doi.org