How do pathogens disarm plant immunity?
We discovered a widespread strategy used by plant bacterial pathogens: they directly cleave a conserved immune signaling molecule produced by plant immune receptors.
www.biorxiv.org/content/10.6...
NAD to the bone: How bacteria put phages under aRES-t … and how phages fight back
Preview of work IDing aRES, bacterial proteins that deplete cellular NAD+, generating products that cannot be utilized by phage NAD+ regeneration pathways
www.cell.com/cell-host-mi...
Koonin & team dive deep into YprA-family defence systems that define “SPIDER” elements: satellite phage-like defence islands that overlap with the GIs we showed are transferred by jumbo phages. They're packed with ecologically relevant genes. The stuff that moves matters!
doi.org/10.1016/j.ch...
How do human cells defend against viruses?
@sgfern.bsky.social discovers that human immune proteins named ISGs target ancient features of replication shared between animal and bacterial viruses – opening analysis of human immunity to the power of bacterial genetics
www.biorxiv.org/content/10.6...
Bacterial cell division protein FtsZ complexes with a phage protein to activate bacterial immunity
@natmicrobiol.nature.com from Michael Laub & Abel Garcia-Pino
www.nature.com/articles/s41...
New paper alert!! We just discovered a new filament system that is widespread exclusively within CPR bacteria! www.biorxiv.org/content/10.6.... Short thread below. 🦠🔬🚀
Our paper on the YprA family of helicases and their roles in bacterial defence is now out!
We describe ARMADA, a defence system synergise with Druantia and show that both systems spread horizontally on a novel type of mobile genetic element that we call SPIDERs
www.sciencedirect.com/science/arti...
New paper! How do RNAs "know" where to go inside a cell? We dug into the sequence elements that route RNAs to the right place. It turns out that, in mammals, they're surprisingly massive (>200 nt), multipartite, and wonderfully complicated. 🧵
Phage receptor-binding proteins are known for their LEGO-like modularity, but we still do not fully understand their evolutionary potential and how it shapes phage host range. Our new preprint examines this systematically in Klebsiella phages. 🔗 www.biorxiv.org/content/10.6...
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