Associate Professor at The Jackson Laboratory -- Studying gene regulation, genetic variation & human complex traits.
Ryan Tewhey
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Please consider attending and RT. Great lineup of speakers!
Our "Atlas of Variant Effects 2030 Roadmap" is live: zenodo.org/records/1542...
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Proud to share our lab’s first student preprint!🚀@j-c-butts.bsky.social, @alwaysrong.bsky.social, @sagergosai.bsky.social leveraged our MPRA models to predict variant effects, providing scores for the complete catalog of human variation. Grateful for another fun collab with @stevereilly.bsky.social.
Excited to finally present the lab's latest work in defining candidate causal genetic variants that drive autoimmune diseases and their effects on primary human T cell expression and function! www.nature.com/articles/s41...
I’ll be attending #ASHG25! I’m currently hiring for (i) a Senior Research Scientist or (ii) a Postdoc position in my lab. If you’re interested, please reach out to arrange a time to meet and discuss.
Interested in using functional data to understand clinical variants? Been hunting for a good review of the topic? We just wrote one! rdcu.be/exaEU
New preprint @cxqiu.bsky.social @jshendure.bsky.social ! Can we learn regulatory grammars of human cell types — by training on mouse development and transferring across 241 mammalian genomes? Introducing STEAM & a whole-organism scATAC-seq atlas from E10 to birth.
www.biorxiv.org/content/10.6...
Exited to share our recent work on viral cis-regulatory elements in collaboration with @tewhey.bsky.social!
We identified >2000 CREs across the genomes of 27 human-infecting dsDNA viruses from the Herpesvirus, Adenovirus, Papillomavirus, and Polyomavirus families.
www.biorxiv.org/content/10.1...
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In 15 yrs of reporting, I've never had so many health & biomed researchers & outreach orgs tell me they're afraid to talk w/press or barred from speaking bc of new comms policies.
I understand the fear of losing funds. I don't know if silence does more harm than good. If you can speak up, pls do.
1/n 🚨Very excited to share our recent work!🚨
To understand gene regulation across diverse environmental conditions and cellular contexts, we treated a broad array of human cell types with three environmental exposures in vitro.
www.biorxiv.org/content/10.1...
