We study selective autophagy in yeast using a combination of cell biology, biochemical reconstitution and structural biology.
The Ragusa Laboratory
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A huge congratulations to @devika-andhare.bsky.social for being selected as this years postdoctoral recipient of the E. Lucile Smith Award for Excellence in Biochemistry from @dartmouthbcb.bsky.social!
Congratulations to Devika for her amazing images of GUVs with tethered liposomes which now appears on the cover of Autophagy.
The Ragusa Laboratory
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The Trump administration has laid it out: comply with their ideological agenda or else…
This is how we lose free thought in American higher education.
Just a few days left to apply! If you do cool molecular/cell biology things and want to start a lab in a supportive department in New England please check out our ad.
Our newest paper which demonstrates the uses of GUVs for monitoring membrane tethering is now available in MBoC www.molbiolcell.org/doi/10.1091/... Congratulations to @devika-andhare.bsky.social for her amazing work.
📢 Pre-print alert 📢 We are excited to share the lab's first research article! We used our artificial cortex system to investigate how membrane composition regulates self-organized cortical dyanamics. Check it out here: www.biorxiv.org/content/10.1...
The Ragusa Laboratory
AAUP
Clara Jeffery
This has been a long journey and it's exiting to see our story about the Atg2-18 lipid transfer complex, headed by Sabrina Chumpen, published in @embojournal.org!
Great teamwork of the labs @arnemoeller.bsky.social, Stefano Vanni, Fulvio Reggiori and Christian Ungermann!
#cryoEM #autophagy #membrane
Happy to share the latest from the lab, led by Daniel Alvarez, in collaboration with @lizconibear.bsky.social. In this AA-MD tour-de-force, we delve deep into the mechanism and energetics of lipid uptake by bridge-like lipid transfer proteins, and we learn a few interesting things along the way...
The Ragusa Laboratory
Amanda Amodeo
Jennifer Landino
Video
Excited to share the first paper from the lab! 🥳 The ATG9 and lipid droplets saga continues! Open source!
Dmitry Shvarev
Atg18 interaction positions Atg2 for efficient lipid transfer into phagophore elongation
Sabrina Chumpen Ramirez, @dmitryshvarev.bsky.social et al
link.springer.com/article/10.1...
media.tenor.com
ALT: a picture of an alien with the words " it 's a trap " on the bottom
During macroautophagy, the de novo formation of the autophagosome at a membrane contact site (MCS) with the endoplasmic reticulum requires directional lipid flux for the growth of the initial phagopho...
Cortical excitability, a phenomenon in which the cell cortex is dynamically patterned with waves of F-actin assembly, has been described in a variety of animal model systems, including embryos of mamm...
www.biorxiv.org
The molecular mechanism of lipid uptake by membrane-anchored bridge-like lipid transfer proteins. https://www.biorxiv.org/content/10.1101/2025.08.01.668188v1
