📢 PUBLISHED @natgenet.nature.com
📰Tumor DNA methylation subtypes predict immunotherapy outcomes in pleural mesothelioma patients in the NIBIT-EPI-MESO study
By Luana Calabrò, Michele Ceccarelli, Michele Maio and colleagues.
⬇️
www.nature.com/articles/s41...
🚨The paper from my postdoc in @graeffjohannes.bsky.social’s lab at @epfl-brainmind.bsky.social is out! We show that memories can be switched on and off by simply changing the « packaging » of DNA in neurons through epigenetic editing. www.nature.com/articles/s41...
📢PUBLISHED @natgenet.nature.com
📰Rapid epigenomic classification of acute leukemia
By Til L. Steinicke, Gabriel K. Griffin, Volker Hovestadt and colleagues.
⬇️
www.nature.com/articles/s41...
📢PUBLISHED @natgenet.nature.com
📰 Interpretable, flexible and spatially aware integration of multiple spatial transcriptomics datasets from diverse sources
By Jia Zhao, Hongyu Zhao and colleagues.
⬇️
www.nature.com/articles/s41...
📢OUT @natgenet.nature.com
📰Bryophytes hold a larger gene family space than vascular plants.
By Shanshan Dong, Yang Liu and colleagues.
⬇️
www.nature.com/articles/s41...
📢OUT TODAY @natgenet.nature.com
📰Limited overlap between genetic effects on disease susceptibility and disease survival.
By Zhiyu Yang, Nina Mars, Andrea Ganna and colleagues.
⬇️
www.nature.com/articles/s41...
✨Don't miss the N&V✨
📰The dawn of bryophyte genomics is here.
By Giacomo Potente, Yuling Yue & Péter Szövényi.
⬇️
www.nature.com/articles/s41...
📢 PUBLISHED @natgenet.nature.com
📰Genomic analyses implicate hormonal and metabolic dysregulation in polycystic ovary syndrome
By Loes M. E. Moolhuijsen, Corrine K. Welt, Tugce Karaderi, Felix R. Day and colleagues.
⬇️
www.nature.com/articles/s41...
Excited to share my PhD work!
The question: How is genome organization established? Here, we developed a low-input Micro-C method, Pico-C, and used it to map chromatin architecture across early stages of fly development.
Here’s a quick Blue-torial 🙂 (1/n)
www.nature.com/articles/s41...
Profiling of pleural mesothelioma samples from 91 patients identifies four DNA methylation subtypes that correlate with response to immune checkpoint inhibition and survival
www.nature.com
CRISPR-based epigenetic editing is used in a cell-type-specific, locus-restricted and temporally controllable manner in the adult mouse brain to modulate memory expression.
The authors present a molecular classification of acute leukemia using 5-methylcytosine signatures, together with a neural network-based classifier for clinical use.
INSPIRE addresses challenges to integrating diverse spatial transcriptomics datasets by combining deep learning with non-negative matrix factorization, revealing shared and context-specific spatial ge...
www.nature.com
A super-pangenome analysis incorporating 123 newly sequenced bryophyte genomes reveals that bryophytes exhibit a larger number of unique and lineage-specific gene families than vascular plants.
Systematic comparison of genome-wide association results for disease risk and disease-specific mortality for nine common diseases across seven biobanks finds limited overlap between genetic effects on disease susceptibility and survival.
www.nature.com
Bryophytes are a widespread group of land plants that occupy nearly all biomes, yet their genetics and evolutionary history have long remained underexplored. Now, a study that generates extensive genomic data for bryophytes highlights de novo gene formation and horizontal gene transfer as key forces that shape bryophyte diversity and adaptation.
Genome-wide analyses identify genetic loci and plasma proteins associated with polycystic ovary syndrome (PCOS). This study highlights the hormonal and metabolic foundations of the disease and explore...
