Nature Genetics is a monthly journal publishing high impact research in genetics and genomics. Part of @natureportfolio.bsky.social
Repost/like=interesting/relevant, not necessarily endorsement.
Nature Genetics
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✨Don't miss the N&V✨
📰The dawn of bryophyte genomics is here.
By Giacomo Potente, Yuling Yue & Péter Szövényi.
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www.nature.com/articles/s41...
Nature Genetics
📢OUT @natgenet.nature.com
📰Bryophytes hold a larger gene family space than vascular plants.
By Shanshan Dong, Yang Liu and colleagues.
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www.nature.com/articles/s41...
📢 PUBLISHED @natgenet.nature.com
📰Genomic analyses implicate hormonal and metabolic dysregulation in polycystic ovary syndrome
By Loes M. E. Moolhuijsen, Corrine K. Welt, Tugce Karaderi, Felix R. Day and colleagues.
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www.nature.com/articles/s41...
📢PUBLISHED @natgenet.nature.com
📰Rapid epigenomic classification of acute leukemia
By Til L. Steinicke, Gabriel K. Griffin, Volker Hovestadt and colleagues.
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www.nature.com/articles/s41...
📢OUT TODAY @natgenet.nature.com
📰Limited overlap between genetic effects on disease susceptibility and disease survival.
By Zhiyu Yang, Nina Mars, Andrea Ganna and colleagues.
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www.nature.com/articles/s41...
📢PUBLISHED @natgenet.nature.com
📰 Interpretable, flexible and spatially aware integration of multiple spatial transcriptomics datasets from diverse sources
By Jia Zhao, Hongyu Zhao and colleagues.
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www.nature.com/articles/s41...
📢 PUBLISHED @natgenet.nature.com
📰Tumor DNA methylation subtypes predict immunotherapy outcomes in pleural mesothelioma patients in the NIBIT-EPI-MESO study
By Luana Calabrò, Michele Ceccarelli, Michele Maio and colleagues.
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www.nature.com/articles/s41...
Nature Genetics
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Nature Genetics
🚨The paper from my postdoc in @graeffjohannes.bsky.social’s lab at @epfl-brainmind.bsky.social is out! We show that memories can be switched on and off by simply changing the « packaging » of DNA in neurons through epigenetic editing. www.nature.com/articles/s41...
Excited to share my PhD work!
The question: How is genome organization established? Here, we developed a low-input Micro-C method, Pico-C, and used it to map chromatin architecture across early stages of fly development.
Here’s a quick Blue-torial 🙂 (1/n)
www.nature.com/articles/s41...
Pico-C, a low-input Micro-C approach, reveals that dynamic three-dimensional genome folding precedes zygotic genome activation in Drosophila.
Profiling of pleural mesothelioma samples from 91 patients identifies four DNA methylation subtypes that correlate with response to immune checkpoint inhibition and survival
www.nature.com
Genome-wide analyses identify genetic loci and plasma proteins associated with polycystic ovary syndrome (PCOS). This study highlights the hormonal and metabolic foundations of the disease and explore...
A super-pangenome analysis incorporating 123 newly sequenced bryophyte genomes reveals that bryophytes exhibit a larger number of unique and lineage-specific gene families than vascular plants.
Bryophytes are a widespread group of land plants that occupy nearly all biomes, yet their genetics and evolutionary history have long remained underexplored. Now, a study that generates extensive genomic data for bryophytes highlights de novo gene formation and horizontal gene transfer as key forces that shape bryophyte diversity and adaptation.
The authors present a molecular classification of acute leukemia using 5-methylcytosine signatures, together with a neural network-based classifier for clinical use.
www.nature.com
INSPIRE addresses challenges to integrating diverse spatial transcriptomics datasets by combining deep learning with non-negative matrix factorization, revealing shared and context-specific spatial ge...
Systematic comparison of genome-wide association results for disease risk and disease-specific mortality for nine common diseases across seven biobanks finds limited overlap between genetic effects on disease susceptibility and survival.
CRISPR-based epigenetic editing is used in a cell-type-specific, locus-restricted and temporally controllable manner in the adult mouse brain to modulate memory expression.
