🚨📜Our new paper out in @AdvSciNews:
ER shape matters for neuronal health - disrupting ER continuity halts neuro-firing as it slows Ca2+ store refill, explaining selective neuronal vulnerability to ER problems in neurodegeneration ðŸ§
a thread to follow advanced.onlinelibrary.wiley.com/doi/10.1002/...
The ER's continuous tubular network is maintained by ER-shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of ...
