Evidence suggests that transcriptionally similar cells can be functionally diverse
go.nature.com/3N4lT2d
Whats most exciting: In a Xenium mouse brain dataset we predicted four GABAergic markers (Gad1, Gad2, Hapln1, Kcnmb2) to co-localize in neuronal projections. Experimental validation confirmed our predictions.
(Col19a1 is used as negative control bellow)
🚨In our new preprint we show that miRNAs act within a precise temporal window to control cell fate decisions in the human forebrain. ðŸ§
A study of miRNA expression dynamics and functions during early human brain development. @mdc-bimsb.bsky.social ‬
Check it out! www.biorxiv.org/content/10.6...
New @biorxivpreprint.bsky.social preprint led by @pranujanp.bsky.social, studying errors such as incorrect primer sequences and contaminated #CellLines in #circRNA papers in high impact factor journals. We found reagent errors in 51% of n=118 circRNA papers in high IF journals in 2022 (1/4)🧪
Really proud to have contributed to this collaboration 🧠✨
Check out! @lstrngr.bsky.social cool new tool!
New paper! How do RNAs "know" where to go inside a cell? We dug into the sequence elements that route RNAs to the right place. It turns out that, in mammals, they're surprisingly massive (>200 nt), multipartite, and wonderfully complicated. 🧵