Bummer that @zachtpennington.bsky.social is missing #ACNP2024 due to stomach flu. But be sure to check out his discovery about how the anterior hypothalamus codes stress 👇
This is one of the most important, surprising, and exciting findings I've been a part of!
Chronic postpartum stress disrupted these adaptations. We then found changes in hippocampal dopamine. The Maze lab previously discovered H3 dopaminylation, which uses dopamine as a histone mark. Could this be the epigenetic mechanism underlying such lasting effects?