Professor @Biologie_UNIGE @MoCel_Geneva
Loves cells under the microscope!
Sophie G Martin
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This protein is essential for cells to communicate with a mating partner. Its discovery also reveals that diverse organisms use convergent pathways (with likely distinct evolutionary origins) to solve the same signalling problem.
"Humbled to receive this recognition. This belongs as much to my team, my family, & to my home, Palestine: the people, the place, the joyful stubbornness to enjoy life."
Cheers buddy @gautamdey.bsky.social
Thx to my mentors @sophiemartinlab.bsky.social, @paveltomancak.bsky.social, & Pierre GΓΆnczy.
Sophie G Martin
Congratulations @sophiemartinlab.bsky.social group for your latest publcation in @natcomms.nature.com Phosphoregulation of the novel hemi-arrestin MAPK scaffold Sms1 prevents untimely mating @mocel.bsky.social @sciencesunige.bsky.social
Arp2/3-dependent actin assembly shapes endosomes and promotes intracellular trafficking in fission yeast
The work from Alejandro Melero @ameleroc.bsky.social and Miguel Basante-Bedoya just out in Current Biology.
www.sciencedirect.com/science/arti...
@biology-unige.bsky.social
How do cells communicate? They use Sms1 ! π
More seriously, Sms1 is the scaffold of the pheromone-MAPK signalling cascade in fission yeast, which @borissieber.bsky.social et al discovered.
Have a look at the paper π
@biology-unige.bsky.social
How do cells communicate? They use Sms1 ! π
More seriously, Sms1 is the scaffold of the pheromone-MAPK signalling cascade in fission yeast, which @borissieber.bsky.social et al discovered.
Have a look at the paper π
@biology-unige.bsky.social
Distinct #Cdc42 protein levels differentially regulate polarized growth and cell fusion in Schizosaccharomyces pombe
The work of @sajjitasaha.bsky.social and @aiswaryasajeevan.bsky.social, with Laura Merlini and Vincent Vincenzetti, now out in @plosbiology.org !
@biology-unige.bsky.social
As initially presented on Biorxiv: bsky.app/profile/soph..., but with a new figure, where we probe pheromone-induced polarized growth.
Endosomes serve as crucial sorting centers that streamline the distribution of cell surface proteins. The early endosome receives traffic from both thβ¦
www.sciencedirect.com
Omaya Dudin π Β¦πΒ¦π¦ Β¦π¬Β¦
Biology-UNIGE
Sophie G Martin
Congratulations to Gautam Dey (EMBL) and Omaya Dudin (University of Geneva) for being awarded the EMBO Gold Medal 2026 in recognition of their outstanding contributions to the #LifeSciences in Europe! π§ͺ https://www.embo.org/press-releases/embo-gold-medal-2026-awarded-to-gautam-dey-and-omaya-dudin/
How do cells communicate? They use Sms1 ! π
More seriously, Sms1 is the scaffold of the pheromone-MAPK signalling cascade in fission yeast, which @borissieber.bsky.social et al discovered.
Have a look at the paper π
@biology-unige.bsky.social
This study identifies the hemi-arrestin Sms1 as the essential scaffold for mitogen-activated protein kinase (MAPK) signalling in fission yeast mating. Phosphorylation detaches Sms1 from the plasma mem...
www.nature.com
This study identifies the hemi-arrestin Sms1 as the essential scaffold for mitogen-activated protein kinase (MAPK) signalling in fission yeast mating. Phosphorylation detaches Sms1 from the plasma mem...
Polarized growth in #Spombe needs Cdc42, but what role does it play in cell fusion? @sajjitasaha.bsky.social @sophiemartinlab.bsky.social &co show that mitotic polarized growth responds linearly to Cdc42 levels, but mating involves a sharp switch-like response @plosbiology.org π§ͺ plos.io/4bvGIhb
The lab is on a roll. 2nd preprint in as many weeks!
High levels of Cdc42 GTPase underlie an all-or-none decision to fuse.
Great team effort led by PhD students @sajjitasaha.bsky.social and @aiswaryasajeevan.bsky.social
www.biorxiv.org/content/10.1...
@biology-unige.bsky.social
Sophie G Martin
This study identifies the hemi-arrestin Sms1 as the essential scaffold for mitogen-activated protein kinase (MAPK) signalling in fission yeast mating. Phosphorylation detaches Sms1 from the plasma mem...
Very excited that our discovery of Sms1 as the #MAPK #scaffold of fission yeast mating has just been published in @natcomms.nature.com!
@biology-unige.bsky.social
www.nature.com/articles/s41...
Very excited that our discovery of Sms1 as the #MAPK #scaffold of fission yeast mating has just been published in @natcomms.nature.com!
@biology-unige.bsky.social
www.nature.com/articles/s41...
Cdc42 is a Rho-family GTPase conserved across eukaryotes, where it plays essential roles in cell polarization. In single-celled yeast systems, Cdc42 is a key driver of symmetry breaking and polarized ...
Very excited that our discovery of Sms1 as the #MAPK #scaffold of fission yeast mating has just been published in @natcomms.nature.com!
@biology-unige.bsky.social
www.nature.com/articles/s41...
