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Very happy to share our pre-print on the enzymatic synthesis of DNA equipped with short oligosaccharides. Great collaboration with Marc Delarue and Laurence Mulard. Congrats to Maria Dalla Pozza and Marc! chemrxiv.org/doi/full/10.... @pasteur.fr @ipdbsc.bsky.social @cnrs.fr

Thrilled to share our article just published in @J_A_C_S on the selection of Ru-modified aptamers! Fantastic collaboration with @hollensteinlab.bsky.social, congratulations to all authors! doi.org/10.1021/jacs...

Thrilled to share our recent pre-print where we studied the stereochemical outcome of phosphorothioate bond formation during ligation. Congratulations to Erwann and Nazarii. Great collaboration with Roche. @pasteur.fr @chem4life.bsky.social @cnrs.fr @ipdbsc.bsky.social chemrxiv.org/doi/full/10....

Interested by 3D modified aptamers? Then check out our recent article by undergraduate student Charlotte and postdoc Usman. nature.com/articles/s4200… @ipdbsc.bsky.social @pasteur.fr @cnrs.fr

Thrilled to share our article @J_A_C_S on the selection of Ru-modified aptamers. 7 years in the making. Congrats to all authors! Great collaboration with @gassergroup.bsky.social pubs.acs.org/doi/full/10.... @pasteur.fr @ipdbsc.bsky.social @cnrs.fr @pierrenicolasbizat.bsky.social

Photodynamic therapy (PDT) harnesses the combination of light, oxygen, and photosensitizers to induce cell death via reactive oxygen species (ROS) formation. Given its intrinsic properties, PDT repres...

pubs.acs.org

The therapeutic and biotechnological utility of synthetic oligonucleotides is constrained by the limited chemical diversity of canonical nucleotides and their susceptibility to nuclease degradation. Inspired by the hypermodified genomes of bacteriophages, ...

Recent studies have demonstrated that stereopure oligonucleotide phosphorothioates (PS), with defined configuration, provide significant advantages over stereorandom mixtures in therapeutic oligonucle...

Aptamers offer distinct advantages over conventional small molecules or antibodies due to their high affinity and specificity. Additional benefits, including small size and ease of modification, further enhance their biomedical potential. Nonetheless, their interaction capabilities remain constrained by the limited chemical diversity of natural nucleobases, restricting the repertoire of targets accessible in vitro and in vivo. This review highlights strategies to overcome these limitations by expanding the chemical diversity of aptamers, including sugar, backbone, and nucleobase modifications, as well as selection approaches for their identification. We discuss structural insights into modified aptamers and explain their potential in practical applications. Finally, key challenges are identified that must be addressed to fully achieve the therapeutic and diagnostic utility of chemically modified aptamers.

Communications Chemistry, Published online: 15 September 2025; doi:10.1038/s42004-025-01629-5Chemical modifications of aptamers can enhance binding properties, however, the design of suitable functional groups remains challenging. Here, the authors introduce cyclooctatetraene (COT)-modified nucleotides in SELEX experiments, identifying COT-aptamers with low nM dissociation constants, highlighting the potential of three-dimensional ligands in aptamer discovery.

Very happy to share our recent article on the synthesis of Ru-complex modified DNA by SPAAC together with @gassergroup.bsky.social Congrats to all authors! @ipdbsc.bsky.social @chem4life.bsky.social @pierrenicolasbizat.bsky.social chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

Alternative methods for the preparation of naïve libraries for SELEX experiments are in dire need, particularly when hydrophobic, bulky, and complex modification patterns are considered. Here, we exp...

Very happy to share our preprint @ChemRxiv on the selection of Ru-modified aptamers. Long in the making. Congrats to all authors. Great collaboration with @gassergroup.bsky.social @pasteur.fr @ipdbsc.bsky.social @cnrs.fr 10.26434/chemrxiv-2025-dd90p