Just out: Probing three-dimensional cyclooctatetraene for nucleobase modification in aptamer selection
Communications Chemistry, Published online: 15 September 2025; doi:10.1038/s42004-025-01629-5Chemical modifications of aptamers can enhance binding properties, however, the design of suitable functional groups remains challenging. Here, the authors introduce cyclooctatetraene (COT)-modified nucleotides in SELEX experiments, identifying COT-aptamers with low nM dissociation constants, highlighting the potential of three-dimensional ligands in aptamer discovery.
