Assistant Professor, Chemical Biology and Drug Discovery, Utrecht U. PhD G.-J.Boons Lab; Post-doc C.Joo Lab TUDelft. https://www.uu.nl/medewerkers/ZLi2
Zeshi Li (Jack)
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The project was led by Lin Rietveld (my first PhD trainee), had been a teamwork with Wei Wu and Filip Zawisza, and received tremendous support from @incarnatolab.bsky.social
How are RNAs presented on the cell surface without any transmembrane domains? In our paper published at Molecular Cell @cp-molcell.bsky.social, we provide mechanistic insights into this pressing question. They form ternary complexes with RNA-binding proteins and heparan sulfate proteoglycans.
This project was co-led by former post-doc of Chirlmin Joo @chirlmin.bsky.social lab, Bhayashree Joshi. Jointly supervised by Vered Raz (LUMC).
Zeshi Li (Jack)
RIP: Professor Dr. Johannes Frederik Gerardus (Hans) Vliegenthart (April 7, 1936 – February 12, 2026)
A leading figure in structural Glycobiology.
www.uu.nl/en/news/in-m...
We have a 3-year post-doc position open. Apply now and join BioBeyond_NL to power up mass spec studies with new chemical biology tools!
www.uu.nl/en/organisat...
Link to the paper: www.sciencedirect.com/science/arti...
Nice Preview from Ling-Ling Chen lab at Shanghai Academy of Natural Sciences. www.sciencedirect.com/science/arti...
Excited to share the very first #preprint since I started my lab at @utrechtuniversity.bsky.social We explored the area of small molecule- #RNA interaction, and present SOLiD-MaP: a #photoproximity labeling platform for mapping small molecule binding site on RNA.
www.biorxiv.org/content/10.6...
Zeshi Li (Jack)
Zeshi Li (Jack)
Now finally peer-reviewed and published in @springernature.com Experimental & Molecular Medicine (EMM)🥳:
www.nature.com/articles/s12...
Our story was published back-to-back with the intriguing paper by Kim et al.:
www.nature.com/articles/s12...
Science update from my postdoc Peiyuan Chai - his work “glycoRNA complexed with heparan sulfate regulates VEGF-A signaling” is now published @nature.com uncovering a new layer or glycoRNA-regulation of growth factor mediated control physiological processes rdcu.be/e1bBX
RNA-targeting small molecules are emerging as promising therapeutic modalities, but their development requires methods that define binding sites and evaluate RNA target selectivity. Existing approache...
