✨ New preprint from C-GEM: Bioinformatics-Guided Discovery of a Thermostable and Highly Promiscuous RiPP Cyclodehydratase.
Link: chemrxiv.org/doi/full/10....
This paper is a fantastic collaboration between the Walker, and Schepartz labs catalyzed by C-GEM.
#NSFfunded
Ribosomally synthesized and post-translationally modified peptides (RiPPs) often contain backbone-embedded oxazoline/thiazoline heterocycles that are installed by enzymes known as cyclodehydratases. These enzymes are of great interest as biocatalysts for ...
