Single task, lightweight, short-context bp res. profile models often perform on par or outperform current large, multi task, long context models on counterfactual prediction. Much to do to improve.
Bonus: robust, efficient interpretation of syntax
Great collab with @jengreitz.bsky.social lab.
Anshul Kundaje
Through this analysis, we found that chromatin accessibility models outperformed the corresponding expression models for predicting effects on gene expression, similar to previous analysis of data from plasmid reporter assays and natural genetic variation.
