Fascinating paper.
Not only association between auto antibodies against immunotegulatory IL-10 and some patients with inflammatory bowel disease.
But also association between these antibodies and HLA risk allele for IBD. What's mechanistic link?
#immunosky #MedSky
www.nejm.org/doi/full/10....
www.nejm.org
Neutralizing autoantibodies against interleukin-10 can result in a phenocopy of monogenic
defects of interleukin-10 signaling in children and may be associated with inflammatory
bowel disease (IBD)...
