RESEARCH
@morignypauline.bsky.social
@ondrej-kuda.bsky.social M Rohm (CAS, Helmholtz Munich)
Multi-omics profiling of cancer cachexia models uncovers a multi-tissue coordinated response🧪
Nature research paper: A deep-learning framework reveals whole-body perturbations at cell level
go.nature.com/3Pjox61
go.nature.com
An analysis of diet-induced obesity using MouseMapper—a suite of foundation-model-based deep-learning algorithms—identifies structural alterations of the infraorbital branch of the trigeminal ganglia.
⭐Using this approach, we identified structural and molecular alterations in facial sensory nerves linked to reduced sensory responses. Similar molecular signatures were also found in trigeminal ganglia from obese humans, underscoring the potential translational relevance of these findings.
🧠 Does brain aging always mean vessel loss?
We found the opposite in some aged brains: maladaptive hypervascularization, linked to cognitive decline and blood-brain barrier damage.
Check it out below!
www.biorxiv.org/content/10.6...
🤝Special thanks to Izabela Horvath, Rami Al-Maskari, Ying Chen, @ilginkolabas.bsky.social and all co-authors for making this possible! @helmholtzmunich.bsky.social
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Our recent work in @Nature, MouseMapper uses foundation-model AI, mapping perturbations in mouse body cell-by-cell, revealed unexpected facial nerve damage.
Proud to see >75K accesses & >60 news stories in the first week. Paper->> www.nature.com/articles/s41... Next www.biorxiv.org/content/10.6...
MouseMapper
An imaging-omics workflow of whole-mouse analysis
Up to single-cell resolution!👹
vDISCO WildDISCO whole-mouse optical clearing
#SpatialProteomics Trigeminal ganglia
VR annotation of major organs, peripheral nerve & Mφ
@erturklab.bsky.social Nature 2026
www.nature.com/articles/s41...
Super happy to see our work published in @nature.com last week 🤩 By combining whole-body tissue clearing, light-sheet microscopy and AI, we mapped obesity-associated remodeling across the entire mouse body in 3D at cellular resolution.
www.nature.com/articles/s41...
@erturklab.bsky.social
Nature Metabolism
Nature
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A deep-learning framework reveals whole-body perturbations at cell level @nature.com @erturklab.bsky.social @dorie00.bsky.social
www.nature.com/articles/s41...
Beautiful work published by my new Lab at @nature.com
today! @dorie00.bsky.social et al. created
MouseMapper, an AI-powered tool that identifies & maps cells/tissues throughout the whole mouse body. We can now use this for different diseases, such as #LongCovid. This is AI being used the right way!
