Together with the Hurt lab and @beckmannlab.bsky.social , we uncovered that Rrp12 coordinates ordered decoding center assembly. Wrongly assembled DC triggers premature recruitment of Rio1 in the nucleoplasm most likely for quality control. #ribosome #cryo-EM
Lau et al. report that Rrp12 coordinates ordered decoding center assembly during 40S
biogenesis by promoting timely assembly factor release and preventing premature rRNA
folding. Rrp12 C-terminal trun...
