Together with the Hurt lab and @beckmannlab.bsky.social , we uncovered that Rrp12 coordinates ordered decoding center assembly. Wrongly assembled DC triggers premature recruitment of Rio1 in the nucleoplasm most likely for quality control. #ribosome #cryo-EM
Lau et al. report that Rrp12 coordinates ordered decoding center assembly during 40S
biogenesis by promoting timely assembly factor release and preventing premature rRNA
folding. Rrp12 C-terminal trun...
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Cheng Lab
Proud to share our latest preprint! 🥳
Using a multidisciplinary approach, we uncover a dual function of the snR37 H/ACA snoRNP - combining pseudouridylation with ribosome chaperone activity within a single RNP.🔬🧬
Challenging the traditional view of snoRNP function. 👇
#cryoEM #ribosome #RNA #snoRNA