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First, using two independent single-cell PBMC cohorts, we inferred patient-level transcriptomic immune programs that capture both SLE-vs-health differences and heterogeneity within SLE.
Our alumna Sophia Müller-Dott was honored with the MTZ Award for Systems Medicine for her PhD work. Congratulations, Sophia! 🎉 A special thanks to Monika and Thomas Zimmermann from the MTZ Foundation for their enduring support of Systems Medicine. 🙌
These programs revealed a rewiring of immune coordination during disease activation, including changes in cell-to-cell interactions and in how transcriptional “tasks” are allocated across immune cell types.
Together, this links systemic immune programs measured in blood to local tissue pathology in lupus nephritis. We see our patient map as a reference where SLE or other autoimmune cohorts can be analyzed. GitHub: github.com/saezlab/meta...