Finally out in @Cellcellpress!
Proteins with long IDRs are prone to misfolding during protein synthesis.
This is prevented by mRNA 3′UTRs that act as mRNA-based IDR chaperones.
www.cell.com/cell/fulltex...
Highly conserved mRNA 3′ UTRs act as co-translational chaperones for intrinsically
disordered regions (IDRs), preventing inter-domain misfolding and enabling biogenesis
of fully active proteins.www.cell.com
If you want to know what 3′UTRs with long conserved sequence stretches do, check out our BioRxiv preprint doi.org/10.64898/202....
They form functional intermolecular 3′UTR-3′UTR interactions that enable co-folding of proteins to rapidly induce transcriptional programs.
What is the role of #poison-exon in regulating splicing factors in stem cells and development? Check out new work from Nathan Leclair and Mattia Brugiolo and many others in my lab @jax.org #RNA #splicing www.biorxiv.org/content/10.6...
Christine Mayr
SAVE THE DATE for the 13th Canadian Developmental Biology Conference — March 7–10, 2027 — bringing together researchers, trainees, and innovators in developmental biology from across Canada and beyond.
See our handy graphical abstract and article for free here:
bit.ly/4vsl845
New lab preprint lead by Ziqing, Siran and Ayse!
doi.org/10.64898/202...
In it they show that:
1) oskar mRNA clustering is driven by the synergistic action of osk concentration, the Staufen RBP and osk RNA palindrome.
Exciting breakthrough technology from the lab, now live in
@cellcellpress.bsky.social
! Instead of cutting the genome where proteins bind (e.g., Cut&Tag), D&D-seq scars the DNA with a deaminase, allowing single cell genome mapping of TFs and chromatin remodellers!
For 40 years the 8-nt ‘Kozak Sequence’ was thought to mark sites of translation initiation. In a new study, we revise this model by identifying an ~80-nt sequence—the extended Translation Initiation Sequence (eTIS)— that guides ribosomes to correct start sites. 🧵
www.biorxiv.org/content/10.6...
Olga Anczukow
Mélanie Laurin
Trcek Lab
Marvin Tanenbaum
Dan Landau
Jon Henninger
New online! RBPscan measures protein–RNA interactions in living cells
Nature Reviews Genetics
Check out our new work in Cell Systems @cp-cellsystems.bsky.social! Much of the biochemistry in the cell is organized by biomolecular condensates, but what mechanisms control the distribution of a given condensate throughout the cell? And is this mesoscale organization important for function?
Nature Reviews Genetics, Published online: 08 June 2026; doi:10.1038/s41576-026-00985-9In this Tools of the Trade article, Dmitry Kretov and Daniel Cifuentes describe RBPscan (RNA-binding protein specificity and contextual analysis via nucleotide editing), a method that measures the strength of in vivo interactions between RNA binding proteins and their RNA targets.
📢 The Ghersi Lab is recruiting!
We are looking for motivated students and postdoctoral fellows interested in stem cell biology, developmental hematopoiesis, and zebrafish genetics.
Interested? Get in touch or share with your network! l1nq.com/d22fg4o
Video
How are biomolecular condensates spatially organized? As example, we focus on fibrillar centers producing ribosomal RNA in the nucleolus. Disrupting this function disrupts their patterning, and disrupting patterning disrupts function. Out in Cell Systems: authors.elsevier.com/c/1nA3C8YyDf... (1/6)
