Congrats 👏 and I can only highly recommend this paper 🕵️
1/8. New preprint! ✨
How spontaneous is spontaneous behavior? 🧠🐭
We found that whole-brain fUSi signals predicted spontaneous behavioral transitions seconds in advance. Inhibiting one node of this transition-prone state, the medial septum, facilitated switching!
www.biorxiv.org/content/10.6...
Coordinated Representational Drift Across the Mouse Cortex https://www.biorxiv.org/content/10.64898/2026.05.05.723038v1
🚨📢 New paper from the lab:
Age-dependent vulnerability to spatial memory interference in APP/PS1 mice (a preclinical model of Alzheimer's disease)
🧵1/6
www.frontiersin.org/journals/agi...
www.nature.com/articles/s41...
Two-author papers are always special.
Using optogenetic stimulation of hippocampal synapses in awake mice and tracking them over approx. 2 weeks, we link synaptic strength, spine volume and their stability. It's confirmed: bigger spines are stronger and more stable 😅
1/ 97% of cortical PNNs are on PV interneurons. But PNN-positive and PNN-negative PV cells don't split into two groups — they sit at different ends of a transcriptional continuum of fast-spiking specialization. New preprint 🧵
BackgroundWhile Alzheimer’s disease (AD) is well known for progressive memory impairment, less is understood about how amyloid pathology affects flexible upd...
My main postdoc work is now published: www.nature.com/articles/s41...! We (myself, Isabel Low, Frances Cho, and @lgiocomo.bsky.social) discovered task-relevant remote representations in entorhinal cortex independent of CA1. #paperthread below! 1/13
New preprint out! Now this one has been a long one coming... Congrats to Tibby and Darcy for pushing it to the finish line. Fast functional 3p calcium imaging in behaving mice
www.biorxiv.org/content/10.6...
Our paper is out today!!! (not an April fool's day joke) Congrats to authors @azulsilva.bsky.social, @belalima-paiva.bsky.social, Ele Pronier, and mostly to the amazing scientist and human being who led this project @facuumm.bsky.social
#neuroskyence #hippocampus
www.nature.com/articles/s41...
▶️ In our new @plosbiology.org study with James Poulet, we show somatosensory contributions to M1 Vm in a forelimb reaching task.
▶️ Surgical removal of somatosensation impacted movement encoding, Vm regulation and its transition to active state, and more!
▶️ Learn more: doi.org/10.1371/jour...
Simon Wiegert
Neurons in medial entorhinal cortex collectively represent discrete nonlocal positions during immobility. During this nonlocal coding, CA1 is uncoupled from entorhinal cortex. These representations ar...
Synchronization of sharp-wave ripples across the dorsoventral hippocampus during sleep supports coordinated reactivation that represents negative experiences more faithfully than positive ones.
In this study, the authors find that synaptic strength predicts spine size and long-term stability via in vivo imaging together with optogenetic stimulation in awake mice. While individual synapses sh...
