#WeekendRead! #InterferonsFriendsOrFoes?! @ruthfranklinlab.bsky.social, Medzhitov, Hoagland, Rodriguez-Morales &co show @science.org that macrophage-derived oncostatin M overcomes type I IFN detrimental responses during severe influenza lung infection by driving AT-II epithelial cell proliferation!
🎉🎉🎉 Can’t wait to see the amazing science that is sure to come from the Sullivan lab!!!
Tissue repair programs must function alongside antiviral immunity to restore the lung epithelial barrier following infection. We found that macrophage-derived oncostatin M (OSM) counteracted the patho...www.science.org
So exciting to see this out!! More cool biology sure to come!! 🤩👀
Can’t wait to read this!! Sure to be a fantastic resource! #InterferonPower
🎉 New preprint from @aybv.bsky.social, grad student extraordinaire!! He found an unexpected function for IFN-I: priming the lung epithelium for repair! (With some help from our beloved macrophages). Congrats to Alan and the rest of the coauthors!
Had a fantastic visit @roswellpark.bsky.social for the Post-Doctoral Symposium!! So many inspiring scientists doing cool work! Grateful for the invitation!
Ivan Zanoni
I’m so proud to have been able to contribute to this story! Check it out for a cool tale about tissue repair under inflammatory conditions! Congrats @daisyah.bsky.social and @ruthfranklinlab.bsky.social on putting out the lab’s first paper 🫁🐁🦠
www.science.org/doi/10.1126/...
Exciting week! Congrats to @xuzhoulab.bsky.social, Ruslan Medzhitov, & coauthors on discovering a new mechanism to regulate inflammation!! 🎉 www.sciencedirect.com/science/arti...
New preprint to share! Incredible collab w/ Fei Chen’s lab: developed in vivo CRISPR screening platform for 🫁 epithelium, allowing single cell perturbation in post-flu repair. Take a peek to see what we found! Huge congrats to the leaders of this work @daisyah.bsky.social & @sundakao.bsky.social 🎉
Ruth Franklin
Ruth Franklin
Ruth Franklin
Ruth Franklin
Tissue repair programs must function alongside antiviral immunity to restore the lung epithelial barrier following infection. We found that macrophage-derived oncostatin M (OSM) counteracted the patho...
Inflammation is an essential defense response but operates at the cost of normal tissue functions. Whether and how the negative impact of inflammation…
Thrilled to start my lab at the @whiteheadinstitute.bsky.social @mit.edu and to join such a special community of creative and inspiring colleagues. The Sullivan Lab asks (1) how and (2) why infections make us sick, bridging immunology and neuroscience to understand host defense at the organism scale
Lab’s 1st preprint!
Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.
@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.
He is on the job market!
#InterferonPower! Thrilled for our latest work @cp-cell.bsky.social! With @danielboehmer.bsky.social, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free👉 authors.elsevier.com/a/1leKGL7PXu...
1st McKinley Lab grad student’s 1st preprint!
@claireang.bsky.social studied how the uterus safely excises massive amounts of tissue during menstruation and pregnancy.
Come for her GORGEOUS images, stay for her incredible discoveries.
www.biorxiv.org/content/10.6...
w/ @akelleher1017.bsky.social
Very excited to hear from Dr Ruth Franklin as the keynote speaker at the 6th Annual Post-Doctoral Symposium at Roswell Park! @ruthfranklinlab.bsky.social
Ivan Zanoni
Zuri Sullivan
Kara McKinley
Come check out my FIRST EVER first author paper! Especially if you’re interested in the interplay between host defense and tissue repair! Turns out they might be more closely linked than one might think! 🧐💭
Kara McKinley
Mike Feigin 🥯
I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵
Alan Y. Baez Vazquez
“I want everyone in my lab to be exposed to many ways of thinking about biology,” says Whitehead Institute’s newest Member, immunologist Zuri Sullivan. “Creative science often comes from making connections across systems, and Whitehead is uniquely well-suited for that.”
shorturl.at/EFsmh
Excited to share my new preprint from the McKinley lab, where we explored regenerative mechanisms across menstruation and pregnancy! We thought specialized glands would regenerate everything.
We were wrong.
But the real mechanism turned out to be way cooler :) 🧪🧵
www.biorxiv.org/content/10.6...
During menstruation, an inner layer of the endometrium is selectively shed, while an outer, progenitor-containing layer is preserved to support repeated regeneration. Progress in understanding this co...
www.biorxiv.org
www.biorxiv.org
Type I interferon primes the alveolar epithelium to receive reparative signals from tissue-resident macrophages https://www.biorxiv.org/content/10.64898/2026.06.10.731366v1
