The main focus of our research group, also known as the Kordasti Lab, is the role of the immune system, particularly Tregs, in Bone Marrow Failure syndromes and MPN.
Systems Cancer Immunology Group at KCL
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I’m delighted to share our latest work on severe aplastic anaemia, published in Nature Communications. Using advanced single-cell approaches to dissect immune-mediated marrow failure before and after immunotherapy.
A great collaboration with NIH. www.nature.com/articles/s41...
End of a very long day…..
New paper out! ✨
We built a humanized mouse model of JAK2-mutated MPN by embedding patient MSCs & progenitors in a gelatin scaffold to recreate bone marrow.
It preserves disease genetics and enables research on inflammation, immune control & new immunotherapies.
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