Ever wondered how a eukaryotic transcription factor finds its specific DNA motif in the vast genome? In this preprint, we directly measured the dynamics of this search process in living cells, revealing a cooperative mechanism mediated by disordered regions. 1/10 doi.org/10.64898/202...
doi.org
Tineke Lenstra
Encouraging and full of hope: this study shows that even species on the brink of extinction can regain lost genetic diversity and recover over time.
www.science.org/doi/10.1126/...
📣 16th edition of the French 3R meeting “Replication, Recombination, Repair” - Registrations are open!
📆 May 18 to 21, 2026
📍 Belambra Club Presqu’île du Ponant in La Grande-Motte, France
đź”— www.2026.3r-meeting.fr/page/home/
Delighted to see our work now published at the EMBO Journal! Check also this concomitant paper by the Bai and Mirny labs with an orthogonal approach that aligns well with our measurements www.nature.com/articles/s41... Great system to study how SMCs facilitate/regulate target search in chromatin!
Very excited to announce the FIRST symposium on epigenome editing! These tools are becoming widely used in mol bio, ag & therapy. It's time to bring leaders together to discuss this rapidly growing and exciting field. And why not in Paris! Please register & share! (1/2) ctrlepiedit.sciencesconf.org
Population bottlenecks can lead to evolutionary dead ends by eroding genetic diversity and intensifying inbreeding. Although theory predicts possible escape routes, direct observations of this process...
How diverse is bacterial immunity ?
We report in @science.org how language models allowed us to predict 2.4M antiphage proteins spanning >23K novel potential systems.
đź‘Ź @emordret.bsky.social, @alexhv.bsky.social & al doi.org/10.1126/scie...
Explore them here defensefinder.mdmlab.fr/wiki/refseq_...
The Expanding Roles of Homologous Recombination Proteins in Genome Stability
@labvincenzo.bsky.social review how RAD51 shields DNA from nucleolytic processing, promotes fork reversal, suppresses replicative DNA gaps, binds abasic sites to avert cytotoxic conversion
link.springer.com/article/10.1...
The new #Yeast issue of January-March 2026 (Volume 43, Number 1-2) is now out, with a review on the role of Rad9 in DNA repair, and three research articles spanning the isolation of yeast species from flowers and honeys, and the effects of furanic compounds.
onlinelibrary.wiley.com/doi/10.1002/...
Long‑range chromosome encounters in cells are hard to quantify. Here, the authors induce artificial contacts in yeast and show that intra‑chromosomal interactions form faster than inter‑chromosomal on...
Condensin loop extrusion properties, roadblocks, and role in homology search
@aurelepiazza.bsky.social et al show yeast condensin unidirectionally extrudes long chromatin loops & contributes to biasing donor selection during recombinational DNA break repair
link.springer.com/article/10.1...
The in vivo mechanism, cis-acting roadblocks, and biological functions of DNA loop extrusion by eukaryotic SMC complexes remain incompletely defined. Here, we identify condensin-dependent Hi-C contact...
