Another banger from my UCSF/Genentech Hall colleagues Yifan Cheng and David Julius!
www.nature.com/articles/s41...
Mechanoresilience of #lysosomes conferred by TMEM63A. New study from Angelina S. Kim, Jing Ze Wu, Ruiqi Cai, and Spencer A. Freeman @sickkidsto.bsky.social: rupress.org/jcb/article/...
#Membrane #lipid #Organelles #Immunology #Metabolism
Great summary by @philipcball.bsky.social! Our findings certainly don’t invalidate the central dogma, but rather demonstrate an unexpected (and cool!) structural mechanism by which a sequence-specific DNA is created in a cell. (1/6)
Somatic cancer variants enriched in Alzheimer’s disease microglia-like cells drive inflammatory and proliferative states: Cell www.cell.com/cell/fulltex...
Data from cryogenic electron microscopy combined with hydrogen–deuterium exchange mass spectrometry inform a mechanism for cold-evoked activation of the TRPM8 channel, providing a structural and ...
Our latest work on shape-programmable tissues is out in @science.org. By positioning topological defects in cellular nematics, we encode frustrated 2D force fields that relax into predictable 3D shapes. Collaboration with Marino Arroyo’s lab, led by @pauguillamat.bsky.social at @ibecbarcelona.eu.
So amazing and feels so excited/lucky to see many more papers reporting the Cryo-EM structures of mouse cytoplasmic lattice after ours "Molecular basis of oocyte cytoplasmic lattice assembly" online on March 17th, 2026 (www.nature.com/articles/s41...).
Tissue regeneration Tour de Force from @storerlab.bsky.social. Just beautiful.
Hyaluronic acid and tissue mechanics orchestrate mammalian digit tip regeneration | Science www.science.org/doi/10.1126/...
Interested in non-proteinaceous ubiquitination, induced proximity or glycogen? Then you should have a look at our newest article, “Ubiquitination of glycogen and metabolites in cells and tissues”, just published in Nature: www.nature.com/articles/s41...
Excited to see our new preprint out--Thread coming later this week.
www.biorxiv.org/content/10.6...
Video
Hiten Madhani
Journal of Cell Biology
Nature - Molecular basis of oocyte cytoplasmic lattice assembly
