Nature research paper: Ancient co-option of LTR retrotransposons as yeast centromeres
go.nature.com/4c3kP9A
Evolutionarily related ‘proto-point’ centromeres providing resolution to the evolutionary origins of point centromeres are identified in yeast, and comparison shows they evolved in an ancestor with retrotransposon-rich centromeres and that long-terminal-repeat retrotransposons are the genetic substrate.
Very nice preprint from the Biggins lab highlighting the importance of the Cbf1 transcription factor in kinetochore assembly and centromere function: www.biorxiv.org/content/10.6...
Still left wondering how Cbf1 and Cbf3 interact, as suggested by the old literature on this matter...
Congratulations to @maxhaase.bsky.social on his recent publication from his time in the Boeke Lab at NYU, where he used methods from the Y1000+ consortium! 🥳 We are very proud to have had him as an undergraduate student in our lab. med.nyu.edu/research/boe...
Really nice to see @marstonlab.bsky.social's News & Views piece cover the evolution of budding yeast centromeres in @nature.com. Check it out for a clear and concise breakdown of @maxhaase.bsky.social’s new paper and ours! 🧬
This image is from 2015 and is acquired by the EPIC system on the DSCOVR satellite. Why it is posted with no information I do not know. Many people seem to think this was taken by the Artemis ii crew...
www.nasa.gov/solar-system...
"Nobody will care about your work about sugar metabolism and transporters in Neurospora crassa"
Nobody can predict what can happen with your work.
www.sciencedirect.com/science/arti...
What a fantastic News & Views piece in @nature.com from @marstonlab.bsky.social highlighting recent insights into yeast centromere evolution, including the recent paper from @helsenjana.bsky.social and our own.
Max Haase
www.biorxiv.org
Max Haase
HittingerLab
NYU Langone’s Boeke Lab comprises faculty, postdoctoral fellows, graduate students, and research staff who synthesize an engineered yeast genome.
Solid tumors harbor immunosuppressive microenvironments that inhibit tumor-infiltrating lymphocytes (TILs) through the voracious consumption of glucos…
A NASA camera aboard the Deep Space Climate Observatory (DSCOVR) satellite captured a unique view of the moon as it moved in front of the sunlit side of Earth
www.nasa.gov
Out today - structure of the human HIRA histone chaperone complex bound to nucleosomes. Ever wondered how nucleosomes are assembled in the wake of transcription? It takes a 'hulk of a protein complex'. Work by the amazing Wei Tian weetian558.bsky.social. www.biorxiv.org/content/10.6... 🧵
Our paper is now out in Nature:
“Ancient co-option of LTR retrotransposons as yeast centromeres”
www.nature.com/articles/s41...
A short thread on how retrotransposons helped give rise to yeast point centromeres.
1/14
Max Haase
www.nature.com
Evolutionarily related ‘proto-point’ centromeres providing resolution to the evolutionary origins of point centromeres are identified in yeast, and comparison shows they evolved in an ancestor with re...
Progress in the use of artificial intelligence (AI) to advance scientific discovery has made it increasingly realistic to envision automated “end-to-end science” (ETES) systems: integrated pipelines t...
