The registration deadline for this wonderful meeting is approaching! Be sure to reserve your spot before March 10!
We've got two exciting chromatin talks coming up on Wednesday next week:
@epijenatics.bsky.social from @jbuenrostro.bsky.social's lab and @ambystoma22.bsky.social!
register and join us: us06web.zoom.us/webinar/regi...
Come join us for a great week of science in Dublin this summer! @brianstrahl.bsky.social @vanrechemlab.bsky.social @bonalditiziana.bsky.social @garcialabms.bsky.social @metorrespadilla.bsky.social
Updates after feedback, so now’s the time to advertise! Our work with the late, great Charles Kirkpatrick, a force in Clin. Immunology for 60 yrs. We found that B cell immunodeficient patients of his had a hypomorphic variant in EZH2 caused by a defect in allostery. www.biorxiv.org/content/10.6...
In this #Primer, a variety of #enzyme-tethering techniques, such as DamID, ChIC, CUT&RUN, CUT&Tag, and RT&Tag are highlighted, emphasizing their suitability for single-cell and spatial applications in biological research. 🪢🧬
www.nature.com/articles/s43...
How do compartmentalization & loop extrusion organize eukaryotic genomes beyond classical model organisms?
Hi-C analysis of silkworm chromosomes by Drinnenberg, Muller, Mirny et al reveals new combination of these mechanisms, and a new, secluded “S” compartment
link.springer.com/article/10.1...
New from the lab: cfDNA provides an unexpected window into telomere chromatin state and genome-wide chromatin changes that accompany telomere shortening, from a blood draw. We hope this opens a path toward monitoring telomere biology disorders with a blood test. www.biorxiv.org/content/10.6...
New paper! How do RNAs "know" where to go inside a cell? We dug into the sequence elements that route RNAs to the right place. It turns out that, in mammals, they're surprisingly massive (>200 nt), multipartite, and wonderfully complicated. 🧵