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RESEARCH | PX Chen, Y Tian et al. (CAS) Mitochondrial superoxide production preserves nuclear envelope integrity by controlling lipid peroxidation, with impact on ageing in C. elegans 🧪
2mo
Mitochondrial superoxide production is shown to preserve nuclear envelope integrity by controlling lipid peroxidation, with impact on nuclear and organismal ageing in C. elegans.
dlvr.it
Mitochondrial superoxide regulates nuclear envelope integrity and ageing via redox-mediated lipid metabolism - Nature Metabolism
Nature Metabolism
🚨Check out this new study from our Research Unit member @bjornschumacher.bsky.social on gene expression patterns linked to age deceleration and rejuvenation during Dauer Diapause. Congratulations! 🎉
7mo
Saygin’s new ALS paper — showing nucleoporin alterations — just made the journal front cover @febsletters.bsky.social febs.onlinelibrary.wiley.com/doi/10.1002/... febs.onlinelibrary.wiley.com/doi/10.1002/...
www.cell.com/cell/abstrac... A host organelle (in sea slugs) integrates stolen chloroplasts for animal photosynthesis
7mo
9mo
FEBS Press
Cover illustration Stress granules in iPSCs treated with arsenite (G3BP1 (green) / NUP107 (red) / Hoechst (nucleus)). Image credit: Saygin Bilican. The image refers to Bilican et al., “C9orf72 ALS-ca....
febs.onlinelibrary.wiley.com
Sea slugs steal foreign chloroplasts and store them in specialized organelles that facilitate photosynthesis and eventual digestion to mediate starvation resistance.
www.cell.com
🧓Wie das Altern neurodegenerative Krankheiten treibt 🧠 @thevilchezlab.bsky.social @cecad.bsky.social hat einen direkten molekularen Zusammenhang zwischen Altern und neurodegenerativen Krankheiten identifiziert.
A host organelle integrates stolen chloroplasts for animal photosynthesis
🧓How aging drives neurodegenerative diseases🧠 @thevilchezlab.bsky.social @cecad.bsky.social has identified a direct molecular link between aging and neurodegeneration by investigating how age-related changes in cell signalling contribute to toxic protein aggregation.
👩‍🔬 Today is International Day of Women and Girls in Science! Meet Dunja Petrovic, postdoctoral researcher in the group of @thevilchezlab.bsky.social at the @unicologne.bsky.social
9mo
9mo
4mo
FOR5762
Harmit Singh Malik
Universität zu Köln
Universität zu Köln
CRC1678
David Vilchez
🚀 🚀 🚀 Our latest paper is out now: Age Deceleration and Reversal Gene Patterns in Dauer Diapause. We can learn from nature how aging of a whole organism with completely differentiated tissues can be slowed and how that organism can be completely rejuvenated. onlinelibrary.wiley.com/doi/10.1111/...
8mo
The dauer diapause is a naturally occurring extraordinarily long-lived alternative C. elegans larval stage that, upon dauer exit, lives a normal adult life with full reproductive capacity. Here, we d...
onlinelibrary.wiley.com
Age Deceleration and Reversal Gene Patterns in Dauer Diapause
The review covers proteostasis mechanisms across major organelles, including: • Nucleus • Mitochondria • Endoplasmic reticulum • Golgi apparatus • Lysosomes We also highlight proteostasis in membraneless organelles, such as: • Stress granules • Processing bodies • Nucleolus • Nuclear speckles
4mo