Biologist, Professor at CECAD, University of Cologne.
We study aging, age-related diseases, stem cell biology and proteostasis.
http://www.davidvilchezlab.com/
David Vilchez
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RESEARCH | PX Chen, Y Tian et al. (CAS)
Mitochondrial superoxide production preserves nuclear envelope integrity by controlling lipid peroxidation, with impact on ageing in C. elegans 🧪
The review covers proteostasis mechanisms across major organelles, including:
• Nucleus
• Mitochondria
• Endoplasmic reticulum
• Golgi apparatus
• Lysosomes
We also highlight proteostasis in membraneless organelles, such as:
• Stress granules
• Processing bodies
• Nucleolus
• Nuclear speckles
Saygin’s new ALS paper — showing nucleoporin alterations — just made the journal front cover @febsletters.bsky.social febs.onlinelibrary.wiley.com/doi/10.1002/...
febs.onlinelibrary.wiley.com/doi/10.1002/...
Great collaborative effort by:
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu
@cecad.bsky.social @unicologne.bsky.social @uniklinikkoeln.bsky.social
Our new review on proteostasis of organelles in aging & disease is now online in The FEBS Journal!
We discuss recent insights on how #proteostasis safeguards organelle integrity and function across the cell in #aging and disease
doi.org/10.1111/febs...
🧓Wie das Altern neurodegenerative Krankheiten treibt 🧠
@thevilchezlab.bsky.social @cecad.bsky.social hat einen direkten molekularen Zusammenhang zwischen Altern und neurodegenerativen Krankheiten identifiziert.
🧓How aging drives neurodegenerative diseases🧠
@thevilchezlab.bsky.social @cecad.bsky.social has identified a direct molecular link between aging and neurodegeneration by investigating how age-related changes in cell signalling contribute to toxic protein aggregation.
www.cell.com/cell/abstrac...
A host organelle (in sea slugs) integrates stolen chloroplasts for animal photosynthesis
