We are the Winkler Laboratory at the UKHD and DKFZ Heidelberg
Our focus: #cancerneuroscience of #braintumors ( #glioblastoma #brainmetastases), and beyond.
We use #intravitalimaging , #calciumimaging, #preclinicalmodels and more, to tackle these diseases
Winkler Laboratory
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📢 Late registration for the #BrainConference on Cancer Neuroscience is OPEN!
📍 Rungstedgaard, Denmark
🗓️ 25-28 Aug 2026
👉 Register by 12 July: buff.ly/3IpvSDe
@brainprize.org @naddenmark.bsky.social
📢 #CancerNeuroscience Online Seminar with @michellemonje.bsky.social from Stanford University, USA.
Title: The Neuroscience of Brain Cancers
June 16, from 5-6 PM CEST, please register here: us06web.zoom.us/meeting/regi...
📢 #CancerNeuroscience Online Seminar with Manuel Valiente from CNIO, Madrid, Spain.
Title: Molecular and cellular rationale underlying the heterogeneous impact of metastases on brain activity
June 9, from 5-6 PM CEST, please register here: us06web.zoom.us/meeting/regi...
📢 #CancerNeuroscience Online Seminar with Manuel Valiente from CNIO, Madrid, Spain.
Title: Molecular and cellular rationale underlying the heterogeneous impact of metastases on brain activity
June 9, from 5-6 PM CEST, please register here: us06web.zoom.us/meeting/regi...
Scientists from DKFZ and HI-STEM have deciphered a key mechanism that contributes to treatment failure in acute myeloid leukemia (AML). This discovery lays an important foundation for more precise and long-term successful treatment strategies. @cp-cellstemcell.bsky.social
t1p.de/brfxf
Our new preprint on calcium signaling in brain metastases is now on bioRxiv!
Thrilled to share the core work of my doctoral thesis in the @winklerlab.bsky.social, together with @nielsolshausen.bsky.social, @matthiakarreman.bsky.social and many more!
What if brain metastatic cells do not act alone, but form #networks to help them grow?
In our new #preprint, we show that #brainmetastases form malignant, gap-junction mediated #networks that drive cell cycle progression & neural features through Ca²⁺ signaling.
www.biorxiv.org/content/10.6...
🧵👇
Happy #FluorescenceFriday!
Gap junction inhibition disconnects tumour networks in brain metastases and silences Ca²⁺ oscillations that drive proliferation.
More in our recent preprint : www.biorxiv.org/content/10.6...
Video
Video
1/n Excited to share our new paper in Nature Cancer 🦀
Meet Hetairos (Greek- “companion”): an AI model that predicts >100 methylation-defined CNS tumour subtypes directly from a routine H&E slide 🧠
State of the art diagnostics- from the slide that’s already on every pathologists’ desk 🧵
Super excited to see our new preprint on calcium signalling in brain metastases now out on bioRxiv!
Very thankful to be part of @winklerlab.bsky.social and working so closely with @nilshebach.bsky.social under the guidance of @matthiakarreman.bsky.social and Frank Winkler and all our collaborators.
Manuel Valiente, DVM, PhD - Molecular and cellular rationale underlying the heterogeneous impact of metastases on brain activity
Scientists from the German Cancer Research Center (DKFZ) and the HI-STEM* Stem Cell Institute have deciphered a key mechanism that contributes to treatment failure in acute myeloid leukemia (AML). The...
t1p.de
Deutsches Krebsforschungszentrum (DKFZ)
What if brain metastatic cells do not act alone, but form #networks to help them grow?
In our new #preprint, we show that #brainmetastases form malignant, gap-junction mediated #networks that drive cell cycle progression & neural features through Ca²⁺ signaling.
www.biorxiv.org/content/10.6...
🧵👇
Nils Hebach
Nils Hebach
Matthia Karreman
Video
Areeba Patel
What if brain metastatic cells do not act alone, but form #networks to help them grow?
In our new #preprint, we show that #brainmetastases form malignant, gap-junction mediated #networks that drive cell cycle progression & neural features through Ca²⁺ signaling.
www.biorxiv.org/content/10.6...
🧵👇
