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September #ImageOfTheMonth is from @rkinet.bsky.social from @imn-bordeaux.bsky.social This is a maximum projection of a confocal image of a microglia cell (blue) and its nucleus (red), internalising multiple nanoparticles (yellow), one day after supranigral injection in C57B6-J mouse

I'm really excited by the release of our new article in Science Advances. We show here different pathological pathways induced by the inoculation of large or small α-synuclein aggregates, implying several possible concomitant mechanisms in the pathogenesis of Parkinson's disease.

11mo

9mo

"Differential pathological dynamics triggered by distinct Parkinson patient–derived α-synuclein extracts in nonhuman primates", by Rémi Kinet and al. 🧠 Published in Science Advances. For more : www.science.org/doi/10.1126/... @neurobordeaux.bsky.social @benjamindehay.bsky.social

BIC_Bordeaux

11mo

www.science.org

Distinct α-synuclein assemblies trigger distinct neurotoxic cellular pathways.

Differential pathological dynamics triggered by distinct Parkinson patient–derived α-synuclein extracts in nonhuman primates

Institute of Neurodegenerative Diseases