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🚨 Our study is online @cp-neuron.bsky.social! A fun read for all you neuroimmunology aficionados! This study proposes that targeting innate immunity/lymphatics in female & male E4 carriers might lead to different cognitive outcomes, highlighting the need for immunotherapies tailored to each sex. 👇
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Sandro Da Mesquita
Sex-specific APOE4-dependent innate immunity regulates meningeal lymphatics, brain lipids, neuroinflammation, and cognition: Neuron www.cell.com/neuron/fullt...
2mo
Sandro Da Mesquita
Delivanoglou et al. show that expression of APOE4, a risk factor for Alzheimer’s disease, leads to sexually dimorphic lymphatic and inflammatory responses in mice and humans alike. Suppressing APOE4-i...
www.cell.com
Sex-specific APOE4-dependent innate immunity regulates meningeal lymphatics, brain lipids, neuroinflammation, and cognition