Assistant Professor | Dept. of Neuroscience @ Mayo Clinic | Understanding the role of the meningeal lymphatic system in CNS aging & degeneration 🤓🧠🧪🔬 | Views=own.
https://www.mayo.edu/research/labs/meningeal-lymphatics-neurological-disorders
Sandro Da Mesquita
Most assume implants fail slowly over months. The moment an electrode enters the brain, microglia rush toward it within seconds, like fingers reaching for a splinter. Blood vessels leak. The BBB breaks. Inflammation starts instantly.
#BCI #NeuralEngineering #Neurotech
This isn’t a “could face” situation.
It’s a “are facing” situation. And brain drain will continue to happen as long as we undermine science in the US.
www.nytimes.com/2026/04/04/b...
We're making it easy for NIH and HHMI funded scientists to publish @jem.org! Learn more here 👉 hubs.la/Q048m0xN0
Excited to announce our new study (w/ @maxkrummel.bsky.social) published today @nature.com: Macrophages “hold our living identities” by taking tiny bites from living cells and presenting this information to CD8 T cells.
www.nature.com/articles/s41...
#immunology #cellbiology @immunox.bsky.social
Neuron
Macrophages can sample antigens from living cells through a trogocytosis-like mechanism that routes ingested material away from degradation, a finding that delineates a previously unknown pathway...
🚨 Our study is online @cp-neuron.bsky.social!
A fun read for all you neuroimmunology aficionados!
This study proposes that targeting innate immunity/lymphatics in female & male E4 carriers might lead to different cognitive outcomes, highlighting the need for immunotherapies tailored to each sex. 👇
Proud and very excited to be part of this publication (and this team ofc)🤓🧠!
APOE4 impacts BAMs, meningeal immunity + lymphatics, and neuroinflammation differently in females vs. males, across mouse models and human data!
Sandro Da Mesquita
Sandro Da Mesquita
Amy C Fan (she/her)
Shanon Rego
ALT: a man in a cowboy hat with the words that 's the deal on his face
Delivanoglou et al. show that expression of APOE4, a risk factor for Alzheimer’s disease,
leads to sexually dimorphic lymphatic and inflammatory responses in mice and humans
alike. Suppressing APOE4-i...
Delivanoglou et al. show that expression of APOE4, a risk factor for Alzheimer’s disease,
leads to sexually dimorphic lymphatic and inflammatory responses in mice and humans
alike. Suppressing APOE4-i...
Delivanoglou et al. show that expression of APOE4, a risk factor for Alzheimer’s disease,
leads to sexually dimorphic lymphatic and inflammatory responses in mice and humans
alike. Suppressing APOE4-i...
Delivanoglou et al. show that expression of APOE4, a risk factor for Alzheimer’s disease,
leads to sexually dimorphic lymphatic and inflammatory responses in mice and humans
alike. Suppressing APOE4-i...
How to comply with NIH and HHMI publication policies | Rockefeller University Press
How to comply with NIH and HHMI publication policies
Rockefeller University Press is honored to offe...
Delivanoglou et al. show that expression of APOE4, a risk factor for Alzheimer’s disease, leads to sexually dimorphic lymphatic and inflammatory responses in mice and humans alike. Suppressing APOE4-induced innate immunity had contrasting effects on cognition in females and males, highlighting the need for immunotherapies tailored to each sex.
Publishing in JEM enables authors funded by National Institutes of Health (NIH), Howard Hughes Medical Institute (HHMI), and other funders an easy pathway to compliance. Learn more: rupress.org/pages/nih-hh...
