The paper:
www.cell.com/neuron/fullt...
And the press releases:
- In English
www.ox.ac.uk/news/2026-06...
- And in French
www.insb.cnrs.fr/fr/cnrsinfo/...
🥁We discovered that learning evokes brief 2-Hz oscillatory bursts in the hippocampus.
These bursts coordinate neuronal activity across the medial temporal lobe and organize patterns of coactivity among individual neurons during learning and memory recall.
😴Those coactivity motifs are later reactivated in hippocampal ripples during post-learning rest.
The stronger this reactivation, the better memories were recalled later.
We also observed similar 2-Hz oscillations during REM sleep (just like theta oscillations in other mammals !)
🧠Together, these findings reveal a mechanism linking learning, memory consolidation, and recall.
They also suggest that the two-stage model of memory extends to humans. However, the oscillation pacing wake activity is slower and less continuous in humans: ~2 Hz and occurring in brief bursts.
🧵 How does the human brain turn experiences into memories?
During my four years of PhD at Oxford, I investigated this question through a collaboration between Oxford, Toulouse, and Paris, recording directly from the human brain during a relational memory task.
🎉Excited to share that this work is now published in Neuron.
Huge thanks to David Dupret, Leila Reddy, all collaborators, clinicians, colleagues, and especially the participants who made this work possible.
Paper and press releases in the replies.
#Neuroscience #Memory #Hippocampus #Neuron
New unit paper: "A learning-evoked slow-oscillatory architecture paces population activity for offline reactivation across the human medial temporal lobe" published in @cp-neuron.bsky.social www.bndu.ox.ac.uk/papers/learn...
